env Antibody

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Code	CSB-PA319642XA01HQG
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Target Background

Product Details

Full Product Name

Rabbit anti-Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) env Polyclonal antibody

Uniprot No.

P14075

Target Names

env

Alternative Names

envEnvelope glycoprotein gp62 antibody; Env polyprotein) [Cleaved into: Surface protein antibody; SU antibody; Glycoprotein 46 antibody; gp46); Transmembrane protein antibody; TM antibody; Glycoprotein 21 antibody; gp21)] antibody

Raised in

Rabbit

Species Reactivity

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Immunogen

Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) env protein

Immunogen Species

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.; The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.

Gene References into Functions

Taken together, separate intracellular localizations of GLUT1 and HTLV-1 Env are required for the fusion activity and infectivity of HTLV-1 Env. PMID: 25339765
These results indicate that SU domain independently influences the preferential T cell immortalization tropism irrespective of the envelope counterpart transmembrane (TM) domain. PMID: 23785214
gp46 expression was highest in the anaplastic large cell type, followed by the pleomorphic type and Hodgkin's-like type PMID: 21091835
hDlg stabilizes HTLV-1 envelope glycoproteins at the virological synapse formed between infected and target cells, hence assisting the cell-to-cell transmission of the virus PMID: 15286176
sequence of the entire env gene of 65 HTLV-I isolates originating from Gabon, French Guiana, West Indies, and Iran PMID: 15665642
investigated the functional role of the glycine-rich segment, Met-326 to Ser-337; fusion function appears to require flexibility within the glycine-rich segment and hydrophobic contacts mediated by this segment PMID: 15767455
distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry PMID: 15955807
The study finds that the fusion activity of HTLV-1 Env is controlled by an SU CXXC-mediated isomerization of the intersubunit disulfide. PMID: 18480461

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Subcellular Location

[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.; [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.

Database Links

KEGG: vg:1491939

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env Antibody

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Target Background