Recombinant Mouse Proto-oncogene tyrosine-protein kinase receptor Ret (Ret), partial

1. 7-DHC efficiently supports Ret signaling in vitro. PMID: 27334845
2. Results showed that Mn-mediated age-related hearing loss involved a decreased expression and phosphorylation levels of c-Ret in spiral ganglion neurons. PMID: 27824154
3. Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRalpha1 or RET Impairs Normal Cerebellar Motor Learning PMID: 28591570
4. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. PMID: 27396331
5. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. PMID: 27607574
6. Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases. PMID: 28899900
7. Authors did not find evidence for genetic interaction between Ret and Sema3d affecting survival, presence of myenteric plexus or intestine transcriptome. PMID: 28334784
8. findings uncover a novel spinal circuit that mediates crosstalk between touch and pain pathways and suggest that some early RET positive Dorsal Horn neurons could function as pain "gating" neurons. PMID: 27545714
9. Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development. PMID: 28506996
10. we described a RET-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ PMID: 27707970
11. These data provide the first evidence for a physiologic role of these isoforms in RET pathway function. PMID: 27226544
12. Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. PMID: 26904955
13. Ret and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later. PMID: 25838128
14. Parkin and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars compacta dopaminergic neurons and their innervation in the striatum. PMID: 25822020
15. the Ret signaling pathway is important for podocyte survival and recovery from glomerular injury in vivo PMID: 25587123
16. RET coupling to ERK and Akt depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth. PMID: 25635057
17. we analysed non-thermal, atmospheric pressure, plasma irradiation mediated effects in melanocytic tumors which spontaneously developed in HL-RET-mice PMID: 24721948
18. the neurotrophic factor receptor RET drives haematopoietic stem cell survival, expansion and function; haematopoietic stem cells express RET and its neurotrophic factor partners are produced in the haematopoietic stem cell environment PMID: 25079320
19. TNFR1 exerts a dual role in nociceptor information processing by suppressing TrkA and enhancing Ret signaling in peptidergic and nonpeptidergic nociceptors, respectively. PMID: 24811380
20. only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51 PMID: 24425877
21. These data establish mTOR as a key mediator of RET-mediated cell growth in thyroid cancer cells and provide a rationale for combinatorial treatments in thyroid cancers with oncogenic RET mutations. PMID: 23828865
22. STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms. PMID: 23872421
23. SorLA acts as sorting receptor for the GDNF/GFRalpha1 complex, directing it from the cell surface to endosomes. PMID: 23333276
24. our data demonstrate that RET/GFRalpha signals are dispensable for thymic T cell development in vivo PMID: 23300832
25. This study identifies the proto-oncogene RET as a novel component of the foetal male germ cell development pathway. PMID: 22360967
26. Src is a general mediator of selective autophagic targeting of adhesion-linked kinases, and Ret a second FAK-binding tyrosine kinase degraded through autophagy in cancer cells under adhesion stress. PMID: 22732841
27. Partial impairment of tyrosine1062-phosphorylation in c-Ret accelerates age-related hearing loss in heterozygous c-Ret Tyr1062Phe knockin mice. PMID: 21612845
28. this work demonstrates novel inhibitory roles of RetY1015 and provides a possible mechanistic explanation for some of the confounding broad range phenotypes in individuals with congenital anomalies of kidneys or urinary trac. PMID: 22627285
29. The data suggested that Ret protein heterozygosity enhances intestinal adaptation after massive small bowel resection, likely via enhanced epidermal growth factor receptor signaling. PMID: 22421622
30. The transcription factor Runx1 controls FXYD2 expression during the maturation of the somato-sensory system, partly through regulation of the tyrosine kinase receptor Ret. PMID: 22253804
31. RET9 may be the predominant functional isoform in the olfactory neuroepithelium, while RET51 plays a more selective role in a restricted region of the olfactory neuroepithelial sheet. PMID: 21118713
32. Activated Ret protects dopaminergic cell bodies in the substantia nigra pars compacta but does not protect dopaminergic axons in the striatum. PMID: 19767128
33. C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation PMID: 22234463
34. Study shows that the receptor tyrosine kinase Ret is required for motor axon attraction mediated by ephrin-A reverse signaling. PMID: 22304922
35. Results show that Ret is critical for expression of several molecular substrates participating in the detection and transduction of sensory stimuli, resulting in altered physiology following Ret deficiency. PMID: 21395865
36. Letter: BMP-4 down-regulates the expression of Ret in murine melanocyte precursors. PMID: 21530183
37. caspase cleavage of RET is involved in the regulation of adhesion in sympathetic neurons PMID: 21357690
38. SOX9 controls epithelial branching by activating RET effector genes during kidney development. PMID: 21212101
39. GDNF-mediated c-RET kinase activation is associated with the pathogenesis of malignant melanoma PMID: 20422010
40. Expression of c-Ret (phosphorylated/non-phosphorylated) is differentially expressed in motor neurons and in non-neuronal cells in the lumbar spinal cord of ALS model (G93A transgenic mice vs wild-type mice). PMID: 21283077
41. Binding of the transcription factors NXF, ARNT2, and SIM2 to RET depends on the RET polymorphism of Enh2 and affects RET expression and the development of Hirschsprung's disease. PMID: 20977903
42. Results implicate Ret/GDNF as a potent pleiotropic factor able to influence pituitary physiology during a period of high plasticity. PMID: 21239429
43. Withaferin A is a natural RET-inhibitor with efficacy to treet metastatic medullary thyroid cancer in a murine model. PMID: 21134556
44. suppression of budding by BMPs and possibly other factors in non-budded zones of the Wolffian duct may be regulated in part by increased PKA activity, probably partially through downregulation of Ret/GFRalpha1 coreceptor expression. PMID: 20816800
45. find that the receptor tyrosine kinase rearranged during transformation (Ret) binds to protocadherins (Pcdhs) in differentiated neuroblastoma cells and is required for stabilization and differentiation-induced phosphorylation of Pcdh proteins. PMID: 20616001
46. This study uncovers a conserved interaction between DJ-1 and Ret-mediated signaling and a novel cell survival role for DJ-1 in the mouse. PMID: 20386724
47. local degradation of Ret in axons dictates whether GDNF family ligands act as retrograde survival factors PMID: 20392937
48. results indicate that enteric neural crest-derived cells death is a principal cause of intestinal aganglionosis in a Ret hypomorphic state, and suggest that the inhibition of cell death is a route to the prevention of Hirschsprung disease PMID: 20392943
49. Angiotensin II-induced activation of c-Ret signaling with RAS is critical in ureteric bud branching morphogenesis PMID: 19961928
50. Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. PMID: 20160347

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KEGG: mmu:19713

STRING: 10090.ENSMUSP00000032201

UniGene: Mm.57199