Recombinant Drosophila melanogaster Embryonic polarity protein dorsal (dl), partial

1. Dorsal, a Drosophila homolog of NF-kappaB, patterns the dorsal-ventral axis in the blastoderm embryo. During this stage, Dorsal is sequestered outside the nucleus by the IkappaB homolog Cactus. Dorsal accumulates on the ventral side of the syncytial blastoderm. We use modeling and experimental studies to show that this accumulation is caused by facilitated diffusion, or shuttling, of the Dorsal/Cactus complex. PMID: 29097443
2. ere, we describe an extensive, quantitative perturbation analysis targeting the dorsal-ventral patterning gene regulatory network (GRN) controlled by Drosophila NF-kappaB homolog Dorsal. PMID: 27152947
3. The Toll-dorsal pathway is required for resistance to viral oral infection in Drosophila. PMID: 25473839
4. demonstrated that the core promoter composition is an important determinant of transcriptional activity of Dorsal target genes PMID: 24634215
5. Combinatorial effects of uniform and graded factors play an important role in the transcriptional and signaling cascades initiated by Dorsal and may explain differential positioning of gene expression borders by other morphogen gradients PMID: 22981910
6. via relief of Groucho- and Capicua-mediated repression, the Torso and EGFR RTK pathways induce expression of WntD, which in turn limits Dl nuclear localization at the poles and along the DV axis PMID: 22791891
7. we have compared genome occupancy of CBP with 40 different transcription factors in Drosophila embryos and find that master regulators of dorsal-ventral patterning, the transcription factors Dorsal and Medea, target CBP to the genome PMID: 22737084
8. propose that the Dorsal gradient supplies positional information throughout nuclear cycles 10-14 PMID: 20018754
9. time-dependent properties of the Dl gradient are different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo PMID: 19996178
10. Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. PMID: 11752406
11. The Dorsal Rel homology domain plays an active role in transcriptional regulation. Two classes of mutations (termed class I and class II mutations) that alter activation without affecting DNA binding or nuclear import were identified. PMID: 12077338
12. The role of Pelle kinase and Twist in the Dorsal signaling pathway that specifies patterning thresholds of gene expression PMID: 12091311
13. analysis of the interaction between the dorsal rel homology domain and HMG boxes of DSP1 protein PMID: 14607986
14. The maternal Toll signaling pathway sets up a nuclear gradient of the transcription factor Dorsal in the early Drosophila embryo. PMID: 15987775
15. WntD acts as a feedback inhibitor of the NF-kappaB homologue Dorsal during both embryonic patterning and the innate immune response to infection PMID: 16107793
16. Two Xenopus Rel proteins can partially substitute for several, but not all, functions of the dl protein in Drosophila embryos. PMID: 16493693
17. Results support the view that methuselah expression is regulated by dorsal. PMID: 16682822
18. Dorsoventral patterning is not dependent upon Dorsal-mediated repression, reflecting the existence of redundant mechanisms to block Decapentaplegic signaling. PMID: 17035291
19. subcellular localization is negatively regulated by CSN5 PMID: 17295838
20. mutation analyses of genes known to act upstream of Dorsal revealed a requirement for the interleukin receptor-associated kinase family kinase Pelle for layer-specific targeting of photoreceptor axons PMID: 17603113

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KEGG: dme:Dmel_CG6667

STRING: 7227.FBpp0080560

UniGene: Dm.3233