Recombinant Drosophila melanogaster Neurogenic locus protein delta (Dl), partial

1. A new paramutation-like example at the Delta gene of Drosophila has been described. PMID: 28355214
2. Binding of Notch to ligands of the Delta/DLL and Serrate/JAG families from neighboring cells leads to activation of the signaling pathway and is called trans-activation PMID: 28394891
3. miR-124 plays neuroprotective roles in Alzheimer's disease Drosophila by targeting Delta in Notch signaling pathway. PMID: 26592243
4. Notch activation by odorants depends on the Delta/Serrate/Lag2 ligand Delta in select olfactory receptor neurons. PMID: 21315258
5. Differential Vegfr levels affect tip selection only in the presence of a functional Notch system by modulating the expression of the ligand Dll4. PMID: 20871601
6. Delta is endocytosed in a Neuralized-dependent manner from the basolateral membrane. PMID: 20410139
7. Dl transcription and protein levels did correlate with altered N signaling in mutant genotypes. PMID: 9651468
8. results show that sna is required for the Neur-dependent endocytosis of Delta in the mesoderm, suggesting that Sna regulates the ability of mesodermal cells to signal and activate Notch receptors PMID: 12632175
9. Delta is requiredfor the positioning of oocyte in the adjacent younger cyst. PMID: 14536057
10. extension of planar filopodia is promoted by Delta; experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing these membrane specializations mediate long-range lateral inhibition PMID: 14654840
11. two previously detected genotype/phenotype associations between bristle number and variants in the introns of Delta cannot be explained by linkage disequilibrium between these variants and nearby nonsynonymous variants PMID: 15020426
12. Faf plays a role similar to that of Neur in the Delta signaling cells; by deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling PMID: 15469967
13. Proteolytic cleavage of Dl by Kul represents a general mechanism for refining and maintaining the asymmetric distribution of Dl PMID: 15576412
14. Altogether, these data support a model whereby proteolysis can modulate Delta ligand activity independently of endocytosis. PMID: 16487968
15. the Hox genes, Sex combs reduced (Scr) and Ultrabithorax (Ubx), establish differential expression of the proneural gene achaete (ac) by modifying expression of the ac prepattern regulator, Delta (Dl), in T1 and T3 legs, respectively PMID: 17107776
16. Fringe sensitizes Notch on glia to axon-derived Delta PMID: 17215308
17. Delta loss-of-function alleles dominantly suppress Msk gain-of-function phenotypes in the developing wing. PMID: 17628519
18. HNT functions in the determined R1/R6 precursor cells to allow Delta transcription to reach high enough levels at the right time to induce the cone-cell determinants Prospero and D-Pax2 in neighboring cells PMID: 19234063
19. In R1/R6/R7 photoreceptor precursors, unidirectional signaling depends on Dl's ability to inhibit Notch within the same cell. Loss of Dl-mediated cis-inhibition reverses the direction of lateral signaling. PMID: 19631544
20. suggests that within a NB lineage Delta is dispensable for sibling cell fate specification PMID: 19782677

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KEGG: dme:Dmel_CG3619

STRING: 7227.FBpp0083153

UniGene: Dm.7687