Recombinant Mouse RE1-silencing transcription factor (Rest), partial

1. Findings identified REST as the first epigenetic modifier involved in promoting not only neuroendocrine differentiation but also EMT and stemness in advanced prostate cancer upon its downregulation. PMID: 28256535
2. REST has a central role in maintaining both the quiescent and proliferation states of adult hippocampal neural stem cells by binding and regulating distinct target genes. PMID: 27819263
3. Modulation of nuclear REST by alternative splicing is a potential therapeutic target for Huntington's disease. PMID: 28524599
4. Negative regulation of REST on NR2B in spinal cord takes part in the exacerbation of bone cancer pain. PMID: 27732941
5. Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator. PMID: 28391636
6. a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation. PMID: 27956497
7. results highlight the significance of REST function in lens fiber formation, which is necessary for maintaining an intact lens structure PMID: 27631609
8. Repressor element-1 silencing transcription factor levels affect the functional expression of voltage dependent calcium channels and the migratory activity in immortalized gonadotropin hormone releasing neurons. PMID: 27349310
9. Data indicate that levels of repressor element-1 silencing transcription factor (REST) are elevated in polyubiquitin-B knockout (Ubb -/-) cells. PMID: 28285139
10. Results identified REST as a novel target gene that was negatively regulated by miR-218 in cardiomyocytes hypertrophy process. PMID: 27258257
11. Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs by negatively regulating the Wnt/beta-catenin signaling pathway and positively regulating the cardiogenic TF Gata4 PMID: 26864965
12. These results suggest that REST-mediated chromatin remodeling is required in neural progenitors for proper S-phase dynamics, as part of its well-established role in repressing neuronal genes until terminal differentiation. PMID: 26745185
13. The transcriptional repressor REST represses miR-21 and, thus, regulates self-renewal in E14Tg2a.4 mESCs cultured in the absence of mouse embryonic fibroblast feeder cell effects. PMID: 26209818
14. Data suggest that Rest regulates early osteoblast differentiation via modulating Rest expression that is independent of Osx expression. PMID: 25727884
15. Cultured astrocytes gradually became refractory to reprogramming, in part by the repressor REST preventing Neurog2 from binding to the NeuroD4 promoter. PMID: 26119235
16. REST expression in nerve injury is decreased following alternative splicing which in turn controls PACAP expression. PMID: 26518165
17. REST knockdown affects the capacity of progenitor cells to generate neurospheres in the subventricular zone. PMID: 25691247
18. REST regulates differentiation and maturation of neural progenitor cells. PMID: 26538656
19. the expression of REST during the early neural crest specification stage was necessary for the normal development of melanoblasts to cover all of the skin. PMID: 25818501
20. We propose a mechanism for transcriptional activation in neurons that involves REST-guided targeting of TET3 to the DNA for directed 5hmC generation and NSD3-mediated H3K36 trimethylation PMID: 25843715
21. transcriptional repressor REST is active in pancreas progenitors where it gates the activation of part of the beta cell differentiation program PMID: 26156633
22. miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth. PMID: 25406064
23. Genes under REST control are actively repressed in stem cells by a balance of the H3K4me3 mark and a repressor complex that relies on histone deacetylase activity. PMID: 25250711
24. p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation. PMID: 25074806
25. Rest knockout mice do not have proper gastric retention and the reduction of acetylcholinesterase activity in NCC-derived myenteric plexus in the stomach was detected. PMID: 25135772
26. CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors. PMID: 25197063
27. miR-22 and miR-124 are expressed in the cortical wall where they target components of the CoREST/REST transcriptional repressor complex, thereby regulating doublecortin transcription in migrating neurons. PMID: 24794437
28. Higher REST levels resulted in lower levels of target genes, indicating that REST can fine-tune gene expression through repression. PMID: 25505318
29. RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase PMID: 24861183
30. increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse PMID: 25261598
31. As a result of differences in the components and targets of the Rest complex, its functional roles may differ in embryonic stem cells and epiblast stem cells. PMID: 24752154
32. Identification of a broad range of genes modulated by REST in mouse liver. PMID: 24329414
33. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058
34. Our results reveal REST and microRNA dependent mechanisms that restrict NPAS4 expression to the brain PMID: 24291638
35. results identify REST/NRSF as a critical factor linking neuronal activity to the activation of intrinsic homeostasis and restoring a physiological level of activity in the entire neuronal network PMID: 24149584
36. miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation. PMID: 23754622
37. REST as a crucial transcriptional regulator for the Kv7.4 potassium channel subunit. PMID: 23242999
38. REST knockout mice exhibit increased vulnerability to neurotoxicity of MPTP compared to wildtype. PMID: 22766071
39. A conserved region of human and mouse SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST binding motifs. PMID: 23250796
40. Evidence is provided of the contribution of inappropriate REST-mediated transcriptional repression to the widespread changes in coding and non-coding gene expression. PMID: 23145961
41. REST regulates ESC pluripotency in culture condition- and ESC line-dependent fashion PMID: 22952733
42. finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression PMID: 23022299
43. central role for REST during neural development in promoting neural stem/progenitor cell self-renewal while restricting the generation and maturation of neurons and oligodendrocytes PMID: 22791895
44. threshold dose of pentylenetetrazol that induced clonic and tonic seizures was significantly higher in NRSF conditional knock-out mice compared with controls. Median lethal dose of PTZ in NRSF cKO mice was considerably higher than that of control mice. PMID: 22472570
45. Data show that Egr1-induced activation of the Ca(V)3.2 promoter was effectively counteracted by the repressor element 1-silencing transcription factor (REST). PMID: 22431737
46. REST acts as a regulatory hub that coordinates timely repression of pluripotency with neural induction and neural differentiation. PMID: 22162260
47. The Neural-restrictive silencer was located downstream of the transcription start site, and showed a position-dependent repressing activity. PMID: 21705344
48. Data show that Rest plays a role in suppressing the expression of neuronal genes in cultured neuronal cells in vitro, as well as in non-neuronal cells outside of the central nervous system, but that it is dispensable for embryonic neurogenesis in vivo. PMID: 22241837
49. NRSF, specifically REST4, may protect the developing brain from ethanol, providing new evidence that NRSF can be a therapeutic target in fetal alcohol syndrome (FAS). PMID: 21396985
50. The data indicated that the residue cysteine 397 (Cys397) plays important roles in the global folding of NRSF/REST multiple ZnFs domain. PMID: 21951847

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KEGG: mmu:19712

STRING: 10090.ENSMUSP00000079231

UniGene: Mm.28840