egr Antibody

1. Activation of epidermal Dronc induces TNF-dependent but effector caspase-independent nociceptive sensitization in the absence of UV. In addition, knockdown of Dronc attenuated nociceptive sensitization induced by full-length TNF/Eiger but not by a constitutively soluble form. UV irradiation induced TNF production in both in vitro and in vivo PMID: 28492538
2. This study shows that Eiger, the Drosophila TNF-alpha, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-producing cells. PMID: 27076079
3. Rac1-dependent production of an Eiger signaling endosome is a crucial element required for activation of the cell death pathway in fly. PMID: 27054336
4. Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth PMID: 25874673
5. a new requirement for Eiger in eliminating damaged cells during development PMID: 25754009
6. Egr protein activates the JNK pathway to promote bone morphogenetic protein signaling. PMID: 24184102
7. data indicate that dUev1a encodes an essential component of the evolutionary conserved TNF-JNK signaling pathway that modulates tumor progression and cell death in metazoan PMID: 23726905
8. Eiger-induced nonapoptotic cell death signaling requires molecules related to the production of metabolic energy downstream of activated JNK. PMID: 22065747
9. evidence that the JNK pathway scaffold protein, POSH, is involved in TNF (Eiger) signaling in Drosophila PMID: 20933214
10. roles of eiger PMID: 21153308
11. We show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. PMID: 20505310
12. Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling. PMID: 20627081
13. These findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling PMID: 12065414
14. role in triggering janus kinase-dependent apoptosis PMID: 12176339
15. Crystal cell rupture after injury in Drosophila requires egr. PMID: 17356067
16. eiger activates the cellular immune response of the fly to aid clearance of extracellular pathogens; intracellular pathogens, which can already defeat professional phagocytes, are unaffected by eiger PMID: 17381241
17. Soluble processed forms of Eiger, if produced at all in the fly, are unlikely mediators of cell death and that the membrane-proximal portion of Eiger may contain a novel functional domain not previously described within the TNF family. PMID: 19223855
18. Eiger, the Drosophila tumor necrosis factor (TNF), behaves like a tumor suppressor that eliminates oncogenic cells from epithelia through a local endocytic JNK-activation mechanism. PMID: 19289090
19. Drosophila homolog of the TNFalpha gene, eiger, displayed all of the hallmarks of negative elongation factor (NELF)-dependent polymerase stalling. PMID: 19820169

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KEGG: dme:Dmel_CG12919

STRING: 7227.FBpp0087493

UniGene: Dm.13536