Recombinant Mouse Myelin-associated glycoprotein (Mag), partial

1. The combination of trans ganglioside binding and cis homodimerization explains how MAG maintains the myelin-axon spacing and provides a mechanism for MAG-mediated bi-directional signalling. PMID: 27922006
2. We show that myelin-associated glycoprotein or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin receptor p75. PMID: 28522736
3. Results show that MAG is important for axon-glia contact in a model for Charcot-Marie-Tooth disease type 1A, and suggest that its increased expression in patients has a compensatory role in the disease pathology PMID: 22940629
4. the apparent dependency on sulfatide for maintaining Nfasc155 and MAG associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis PMID: 24081651
5. Heteronuclear ribonucleoprotein A1 interacts with an element that overlaps the 5' splice site of Mag exon 12. PMID: 23704325
6. Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. PMID: 23074226
7. MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons. PMID: 22583768
8. myelin-associated glycoprotein (MAG) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath. PMID: 21824506
9. This study suggested that MAG engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and that soluble MAG mitigates excitotoxic damage in vivo. PMID: 21214567
10. Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein. PMID: 20956316
11. While myelin-derived axon growth inhibitor MAG may modulate axon sprouting, it does not play a major role in central nervous system axon regeneration failure. PMID: 20547125
12. The present study provides strong evidence that LPA-induced calpain activation plays a crucial role in the manifestation of neuropathic pain through MAG down-regulation in the DR. PMID: 20420580
13. binds directly, with high affinity, to the receptor for NOGO (NgR);MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury PMID: 12089450
14. MAG-positive shi/shi oligodendrocytes extend processes around axons and finally covered the axon. PMID: 12125072
15. The absence of internodal tomacula in mice with a null mutation of the MAG gene supports a role for MAG in the maintenance of myelin at the paranodal regions. PMID: 12365566
16. These results demonstrate that MAG expression is regulated in response to cortical axotomy, and indicate that it may limit axonal regeneration after CNS injury. PMID: 15896979
17. MAG and complex gangliosides contribute to axon stability in both the CNS and PNS. PMID: 15953602
18. Results describe the differential expression pattern and spatial distribution of L- and S-myelin-associated glycoprotein during development as well as in the adult central and peripheral nervous system. PMID: 16442810
19. In conclusion, as MAG significantly improves the quality of axonal regeneration, it can be used as a new therapeutic approach for peripheral nerve repair with possible focal and temporary application. PMID: 17705198
20. gangliosides inhibit neurite outgrowth by interacting with FRG motifs in the NgR1 and this interaction can also facilitate the binding of MAG to the NgR1 PMID: 18411262
21. MAG-deficient mutants present abnormalities in the structure of myelin sheaths and Ranvier nodes; combined deletion of MAG and Nogo-A causes severe transient hypomyelination. PMID: 18632947
22. This report establishes for the first time that MAG also promotes resistance to axonal injury and prevents axonal degeneration both in cell culture and in vivo. PMID: 19158290

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KEGG: mmu:17136

STRING: 10090.ENSMUSP00000041464

UniGene: Mm.241355