GNAL Antibody

Code CSB-PA002857
Size US$100
  • Western Blot analysis of HEPG2-UV cells using Gα olf Polyclonal Antibody
  • Western Blot analysis of HepG2-UV cells using Gα olf Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
Adenylate cyclase stimulating G alpha protein; olfactory type antibody; Adenylate cyclase-stimulating G alpha protein antibody; DYT25 antibody; G alpha olf antibody; Gnal antibody; GNAL_HUMAN antibody; Guanine nucleotide binding protein (G protein); alpha activating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein (G protein); alpha stimulating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein G(olf) subunit alpha antibody; Guanine nucleotide-binding protein G(olf) subunit alpha antibody; olfactory type antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human Gα olf.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Gene References into Functions
  1. GNAL mutation may represent one of the rare causative genetic factors of isolated laryngeal dystonia. PMID: 27093447
  2. GNAL mutations are not a common cause of dystonia in the Brazilian population PMID: 26810727
  3. We report a novel GNAL mutation in Italian family with adult-onset, dominantly-inherited dystonia PMID: 26725140
  4. Mutations in the GNAL gene may not be a common cause of isolated dystonia in the Chinese population. PMID: 26365774
  5. This study demonstrated that Mutations in GNAL may cause Dystonia. PMID: 25847575
  6. identified two novel GNAL mutations: one heterozygous missense variant in GNAL exon 4, c.289A>G. PMID: 25382112
  7. The findings of this study further support GNAL as causative gene in adult-onset isolated dystonia. PMID: 24408567
  8. This study identified a novel likely disease-causing GNAL mutation in a Serbian patient with cervical dystonia and a classical DYT25 phenotype. PMID: 24729450
  9. Primary dystonia in the Amish-Mennonites is genetically diverse and includes not only the THAP1 indel founder mutation but also different mutations in THAP1 and GNAL as well as the TOR1A GAG deletion. PMID: 24500857
  10. GNAL variants seem to be a rare cause of primary torsion dystonia in our mainly sporadic German sample. PMID: 24151159
  11. Our own data suggest that GNAL mutations do not represent a common cause of dystonia in the U.K. population. PMID: 24222099
  12. The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). PMID: 24144882
  13. GNAL mutations potentially increase ethnic susceptibility to movement disorders induced by dopamine antagonists. PMID: 24535567
  14. Mutations in GNAL gene can cause adult-onset primary dystonia in Chinese patients PMID: 23759320
  15. Familial adult-onset primary dystonia can result from mutations in GNAL. PMID: 23449625
  16. Mutations in GNAL cause primary torsion dystonia. PMID: 23222958
  17. these findings provide important clues to understanding physiological functions of XLGalpha(olf). PMID: 22120635
  18. investigation of whether polymorphisms in the alpha subunit of the Golf gene (A-->G in intron 3, and T-->G in intron 10) are associated with major depression; additionally tested for a parent-of-origin effect in separated gender groups PMID: 11901355
  19. promotes cellular invasion, survival and neuroendocrine differentiation in colon, kidney and prostate epithelial cells PMID: 12037684
  20. No support for the hypothesis that the olfactory G-protein gene is a major susceptibility factor for bipolar disorders. PMID: 12782961
  21. identified a transcriptional variant of the GNAL gene in chromosome 18p11.2 in susceptibility to bipolar disorder and schizophrenia PMID: 16044173
  22. Galpha(olf) variant XLGalpha(olf) interacts with the human adenosine A2A receptor PMID: 16818375
  23. We hypothesized that the G(s)-like subunit Galpha(olf), expressed in D1-rich areas of the brain, contributes to the genetic susceptibility of ADHD. We examined the inheritance pattern of 12 GNAL polymorphisms in 258 nuclear families. PMID: 17166517
  24. This study provides important clues toward understanding physiological functions of XLGalpha(olf). PMID: 19245791

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Involvement in disease
Dystonia 25 (DYT25)
Protein Families
G-alpha family, G(s) subfamily
Tissue Specificity
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
Database Links

HGNC: 4388

OMIM: 139312

KEGG: hsa:2774

STRING: 9606.ENSP00000334051

UniGene: Hs.136295

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