Recombinant Human Leukemia inhibitory factor protein(LIF) (Active)

Code CSB-AP002221HU
Product Type Growth Factor
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P15018
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias LIF, D factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Research Area Immunology
Source E.coli
Gene Names LIF
Expression Region 23-202aa
Product Info Tag-Free
Mol. Weight 19.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 3143918; 2475312; 15146197; 1692837; 14702039; 10591208; 15489334; 3128791; 2730639; 8489250; 14527405; 17652170
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Function LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Subcellular Location Secreted
Protein Families LIF/OSM family
Database Links

HGNC: 6596

OMIM: 159540

KEGG: hsa:3976

STRING: 9606.ENSP00000249075

UniGene: Hs.2250

Pathway Jak-STAT signaling pathway
TNF signaling pathway
Signaling pathways regulating pluripotency of stem cells
Excitatory synapse pathway

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