Recombinant Drosophila melanogaster Protein scalloped (sd)

1. These findings suggest that spatiotemporal expression of transcription factor Sd induces differential growth regulation by Yki during wing disc development, highlighting coordination between Yki and CycE to control growth and maintain homeostasis. PMID: 28143945
2. DNA-binding transcription factor Scalloped mediates both Yorkie overexpression and loss-of-function phenotypes yet is itself dispensable for normal eye development PMID: 29467233
3. found that human E2F1 competes with YAP for TEAD1 binding, affecting YAP activity, indicating that this mode of cross-regulation is conserved PMID: 29207260
4. Data show that Yorkie (Yki) and Scalloped (Sd) are required for epidermal wound closure in the larval epidermis. PMID: 28514643
5. Vestigial protein phosphorylation of serine 215 occurs in the nucleus and requires the presence of Scalloped. PMID: 28322734
6. Data indicate that the TEAD family transcription factor Scalloped (Scalloped) regulates PDGF/VEGFR receptor (Pvr) expression. PMID: 28322737
7. Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage. PMID: 26160905
8. Yorkie and Scalloped are associated with specific cell-fate determination in the context of blood development. PMID: 25454586
9. This study identifies a novel protein Sd-Binding-Protein, SdBP, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. PMID: 23999857
10. Study describe the full breadth of SD expression during Drosophila embryogenesis, and identify a requirement for sd function in a subset of motor neurons. PMID: 23389965
11. Yki controls normal tissue growth by relieving Sd-mediated default repression. PMID: 23725764
12. These results support a critical role for Yki- and its partners Sd and Hth--in shaping the fate map of the eye epithelium. PMID: 21811580
13. The identified nuclear localization signal is likely a classical bipartite signal. PMID: 21731746
14. dE2F1 is needed for Yki/Sd-dependent full activation of these target genes, and a de2f1 mutation strongly blocks yki-induced proliferation in vivo. PMID: 21325133
15. DNA target selectivity of Scalloped. PMID: 20725144
16. the Vestigial/Scalloped transcription complex has a role during wing development in Drosophila melanogaster PMID: 12782275
17. Drosophila sd is involved in wing development as well as neural development. PMID: 15126402
18. Expression of the VGDeltaACT construct in the wing alters the cellular localization of VG and produces a mutant phenotype, indicating that the construct is able to antagonize the normal function of the SD/VG complex. PMID: 17110491
19. Inactivation of Sd diminishes Hpo target gene expression and reduces organ size, whereas a constitutively active Sd promotes tissue overgrowth. PMID: 18258485
20. identify the TEAD/TEF family protein Scalloped (Sd) as a DNA-binding transcription factor that partners with Yki to mediate the transcriptional output of the Hpo growth-regulatory pathway PMID: 18258486
21. Interaction between YKI and SD increases SD transcriptional activity both ex vivo in Drosophila S2 cells and in vivo in Drosophila wing discs and promotes YKI nuclear localization. PMID: 18313299
22. Data show that both Vestigial and Scalloped are required for muscle differentiation, as loss of either leads to a loss of a subset of cardiac or somatic muscle cells in developing embryos, and also that Sd, Vg, and Dmef2 can interact directly. PMID: 18987343
23. at least one of the modifiers is linked to the vestigial region and demonstrate that the background effects modify the spatial distribution of known sd target genes in a genotype-dependent manner PMID: 19064709

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KEGG: dme:Dmel_CG8544

STRING: 7227.FBpp0301994

UniGene: Dm.6072