Recombinant Mouse Nestin(Nes) ,partial

Code CSB-YP015713MO
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Source Yeast
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Code CSB-EP015713MO
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Source E.coli
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Code CSB-EP015713MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015713MO
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Source Baculovirus
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Code CSB-MP015713MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Nes; Nestin
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Gene References into Functions
  1. nestin plays a seminal role in the cell cycle re-entry of cardiomyocytes. PMID: 28834610
  2. results give new insights into the yet underestimated role of proliferating nestin-expressing vascular SMCs during postnatal development and repair of the epididymis. PMID: 29874225
  3. Nestin silencing inhibits proliferation and migration of malignant melanoma cells via G1/S arrest in a Akt-GSK3beta-Rb pathway. PMID: 29270750
  4. In mouse neural stem spheres and neuronal precursors, nestin expression was increased in morphine treated cells whereas it was downregulated in both HAT inhibitor and HAT inhibitor in combination with morphine. PMID: 29111275
  5. These results indicate that the first intron enhancer may be activated in differentiated odontoblasts. Intriguingly, Nestin-GFP expression in the subodontoblastic layer was found to be restricted to the coronal pulp of molars, which is susceptible to tooth injuries. PMID: 29445893
  6. These results reveal that nestin deficiency generates a spontaneous regenerative phenotype in skeletal muscle that relates to a disturbed proliferation cycle that is associated with uncontrolled Cdk5 activity. PMID: 28733456
  7. Nestin promotesneural progenitor cells (NPCs) proliferation via p38-MAPK and EGFR pathways, and reveals the necessity of these pathways in NPCs self-renewal. PMID: 27894083
  8. the loss of Nestin(+) cells might be an etiology to DCM pathogenesis, and these cells could be a promising candidate cell source for study and treatment of DCM patients PMID: 29375111
  9. Nestin regulates neural stem cell migration via controlling the cell contractility PMID: 27477313
  10. demonstrate that following postnatal ablation of granule cell progenitors, Nestin-expressing progenitors, specified during mid-embryogenesis to produce astroglia and interneurons, switch their fate and generate granule neurons in mice. PMID: 28805814
  11. The nestin(+) cells contribute to all subsets of the complex stromal populations that can be found in lymph nodes. PMID: 27574301
  12. nestin may label progenitor cells during inner ear development and may not be a stem cell marker in the mature organ of Corti PMID: 27474107
  13. Nestin(+) cells are one important type of progenitor cell in bone marrow and are associated with bone remodeling. These data indicate that DMP1 plays negative roles in differentiation of Nestin(+) cells and bone formation. PMID: 28647374
  14. Our findings show how Nestin drives hedgehog pathway-driven cancers and the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. PMID: 27496710
  15. Based on a nestin-green fluorescent protein (NGFP) transgenic model, a histological inventory has been performed to deliver an overview of neuronal and glial markers for the various parts of the gastrointestinal tract in newborn (postnatal day 7) and adult mice under homeostatic conditions. PMID: 27519533
  16. EGFR and Nestin showed to have vital role during mice development, and considered to be suitable markers for the study of skin stem cells. PMID: 27105606
  17. Nestin was shown to affect cell number and was significantly enhanced in lungs early during development of pulmonary hypertension. PMID: 26699726
  18. We show that their primary processes follow a tortuous path from the subgranular zone through the granule cell layer and ensheathe local synapses and vasculature in the inner molecular layer. PMID: 27091993
  19. Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells. PMID: 26418130
  20. Our results proposed nestin+ bone marrow derived cells as mobilized candidates in skin injury repair PMID: 26633897
  21. Cryopreservation of the Hair Follicle Maintains Pluripotency of Nestin-Expressing Hair Follicle-Associated Pluripotent Stem Cells. PMID: 25743086
  22. Nestin-positive stem Leydig cells had the capacity to partially restore testosterone production in vivo following transplantation into Leydig cells - disrupted or senescence animal models. PMID: 25418539
  23. The Phactr4 signals were not associated with F-actin fibers but were closely associated with intermediate filaments such as nestin and glial fibrillary acidic protein (GFAP) fibers. PMID: 24748504
  24. Results indicate nestin-expressing fungiform papilla cells and the nestin-expressing hair follicle stem cells have common features of cell morphology and ability to differentiate into multiple cell types. PMID: 24142339
  25. nestin+ cells during hematopoiesis and bone formation are associated with vasculature and include both endothelial and nonendothelial cells. PMID: 24823376
  26. nestin phosphorylation may play an important role in mitotically active neuronal progenitor cells PMID: 24200156
  27. glial cells that originate from nestin-expressing cells and their progeny require Cdk5 for proper development during the early postnatal period PMID: 23991155
  28. localization of Nestin mRNA with Nestin protein in cell protrusions indicates the presence of a regulatory mechanism at the mRNA localization level for the Nestin intermediate filament protein with potential importance for astrocyte functions PMID: 24009167
  29. These findings uncovered a novel role of nestin in regulating TGF-beta1-induced epithelial-mesenchymal transition. PMID: 23552743
  30. 92% of nestin(+) interstitial cells expressed Flk-1. PMID: 24068741
  31. the second intron of the nestin gene drives expression in the mouse heart and a subpopulation of GFP/nestin((+)) cells directly participate in reparative vascularisation PMID: 23459851
  32. Tubule repair that occurs during the recovery process following nephrectomy may involve TGF-beta1-induced nestin expression in immature renal proximal tubule cells and the promotion of renal cell migration. PMID: 22993065
  33. The results of the present study demonstrate that multipotent, nestin-expressing stem cells are present throughout the hair follicle. PMID: 22918245
  34. Downregulation of nestin sensitized podocytes to high glucose-induced apoptosis. PMID: 22614921
  35. Preodontoblasts began to express nestin and Dsp proteins and Dsp mRNA, which increased in their intensity according to the progress of odontoblast differentiation in both incisors and developing molars PMID: 22572386
  36. increased expression in orofacial muscles of dystrophin deficient mdx mice PMID: 22307364
  37. Cdk5 regulates the organization and stability of its own nestin scaffold, which in turn controls the effects of Cdk5. PMID: 21346193
  38. The nestin-expressing stem cells migrate from the BA to the DP as well as into the surrounding skin tissues including the epidermis, and during wound healing, suggesting that the BA may be the source of the stem cells of the skin itself. PMID: 21465525
  39. Characterization of nestin-deficient mice reveals the essential role of nestin in the development of neuromuscular junctions; nestin regulates aberrant Cdk5 kinase activity leading to modulation of certain cell signaling events. PMID: 21832185
  40. The decline in nestin-GFP expression in muscle progenitor cells and its persistence in neural precursor cells in muscle cultures provide an invaluable tool for isolating a population of predifferentiated neural cells with therapeutic potential. PMID: 21304812
  41. Data demonstrate that Class III cells are mature neurons in the adult brain that express nestin. PMID: 21490921
  42. The study shows opposing pattern of nestin and glial fibrillary acidic protein expression in mouse hippocampus occuring in early postnatal development, suggesting that it is important for neural differentiation and positioning in the hippocampus. PMID: 21368556
  43. Nestin is important for the proper survival and self-renewal of neural stem cells. PMID: 20963821
  44. These results suggest that nestin is required for acetylcholine-induced, Cdk5-dependent dispersion of AChR clusters during neuromuscular junction development. PMID: 21278733
  45. results with pNestin-GFP transgenic mice demonstrate that nestin-positive cells proliferate in the dorsal horn in response to peripheral nerve injury PMID: 20673789
  46. This study showed that nestin expression was observed in proliferating endothelial progenitor, but not in mature endothelial cells. PMID: 20421592
  47. Angiogenesis of transplanted skin or healing wounds originates from nestin-driven green fluorescent protein-expressing microvasculature network. PMID: 20225276
  48. Cortical spreading depression elicited by potassium induces a delayed upregulation of nestin not dependent on NMDA receptors. PMID: 11852186
  49. nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas PMID: 11960711
  50. Nestin enhancer requirements for expression in normal and injured adult CNS PMID: 12205672

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Intermediate filament family
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