Recombinant Human Citron Rho-interacting kinase (CIT), partial

1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity. PMID: 27562601
2. Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade PMID: 27551053
3. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans. PMID: 27503289
4. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family. PMID: 27519304
5. Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly PMID: 27453578
6. identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain PMID: 27453579
7. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue. PMID: 26586574
8. Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B, the kinase component of the chromosomal passenger complex. PMID: 27009191
9. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis. PMID: 25665131
10. HIV-1 infection upregulates citK expression at the transcriptional level PMID: 26524911
11. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission. PMID: 23444367
12. High CIT expression is associated with prostate cancer. PMID: 22761715
13. p27 has a role in cytokinesis via the regulation of citron-K activity PMID: 22293177
14. CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin. PMID: 21849473
15. Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis. PMID: 21748597
16. CITRON has a role in proliferation of hepatocellular carcinoma cells PMID: 20369383
17. Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. PMID: 20084519
18. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase and functions in the control of G(2)/M transition in the hepatocyte cell cycle PMID: 12411428
19. Single nucleotide polymorphisms associated with bipolar disorder. PMID: 15983625
20. ASPM and citron kinase co-localize to the midbody ring during cytokinesis. PMID: 17534152

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HGNC: 1985

OMIM: 605629

KEGG: hsa:11113

STRING: 9606.ENSP00000376306

UniGene: Hs.119594