Recombinant Human Thrombopoietin receptor(MPL),partial

Code CSB-YP014755HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P40238
Relevance Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Myeloproliferative leukemia protein;Proto-oncogene c-Mpl; CD110
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence QDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAW
Research Area Immunology
Source Yeast
Gene Names MPL
Protein Names Recommended name: Thrombopoietin receptor Short name= TPO-R Alternative name(s): Myeloproliferative leukemia protein Proto-oncogene c-Mpl CD_antigen= CD110
Expression Region 26-491aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 54.5kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Involvement in disease Congenital amegakaryocytic thrombocytopenia (CAMT); Thrombocythemia 2 (THCYT2); Myelofibrosis with myeloid metaplasia (MMM)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Golgi apparatus, Cell surface
Protein Families Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Database Links

HGNC: 7217

OMIM: 159530

KEGG: hsa:4352

STRING: 9606.ENSP00000361548

UniGene: Hs.82906

Pathway Jak-STAT signaling pathway

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