Recombinant Rat Activity-regulated cytoskeleton-associated protein (Arc)

1. In dissociated rat cortical neurons, H2A.Z.1 and H2A.Z.2 regulate basal expression of largely nonoverlapping gene sets, including genes that code for several synaptic proteins. In response to neuronal activity, rapid transcription of our model gene Arc is impaired by depletion of H2A.Z.2, but not H2A.Z.1. This impairment is partially rescued by codepletion of the H2A.Z chaperone, ANP32E. PMID: 28856239
2. Results suggest that Arc-dependent plasticity during taste learning is required within distinct structures of the medial temporal lobe, depending on the emotional valence of the memory trace. PMID: 29326059
3. This study demonstrated that the Arc expression in auditory and visual cortices after hearing in rats. PMID: 28472857
4. Findings shed further light on the molecular and cellular mechanisms for the formation of fear extinction memory with Arc centrally placed to orchestrate the consolidation of extinction: Arc gates extinction at recall, with high, sustained levels of Arc (through CNQX administration) constraining extinction and decreases in Arc (through Arc antisense administration) facilitating premature extinction. PMID: 28716957
5. We conclude that an increased Arc expression may be related to enhanced synaptic plasticity in the ventral striatum, suggesting that it may be one of the physiological substrates of enhanced learning. PMID: 28185871
6. Hippocampal but not striatal Arc expression decreases with task experience in spatial navigation in rats. PMID: 26976088
7. No changes in either Arc or GAD protein expression were observed in primary auditory cortex in the immediate post-noise exposure period, confirming other reports that auditory cortical plasticity may not occur until later in the development of tinnitus. PMID: 27702572
8. observations support a model in which stalled ribosomes are reactivated to rapidly generate Arc protein. PMID: 27397520
9. These findings reveal a more complete cholinergic signaling that is responsible for carbachol-induced Arc protein expression. PMID: 26895748
10. Maternal stress during pregnancy affects Arc expression in offspring' hippocampus. PMID: 27474832
11. these findings link the pro-neurogenic effects of acute BDNF infusion to induction of Arc/Arg3.1-dependent long-term potentiation in the adult rodent dentate gyrus. PMID: 26888068
12. Intracranial self-stimulation potentiates proto-oncogene proteins c-fos induction across active avoidance conditioning conditions along with increases of activity regulated cytoskeletal-associated protein protein levels in the retrosplenial cortex. PMID: 26774022
13. Female rats which had been pre-exposed to prenatal stress, displayed an "amplified" Arc upregulation in response to postnatal stress compared to unstressed controls, which may reflect a "sensitization" effect of prenatal stress. PMID: 25239865
14. The targeted knockdown of Arc in the brain results in a non-recoverable retrograde amnesia. PMID: 26238574
15. Study demonstrated that ARC is a specific, quantifiable and input dependent molecular marker of circuit activation which can serve to quantify the impact of brain injury and subsequent rehabilitation on whisker sensation PMID: 25682931
16. Recently-generated granule cells showed a robust sustained Arc expression following a discrete behavioral experience. PMID: 26219984
17. Abstinence from developmental exposure to cocaine is associated with alterations in the finely tuned mechanisms that regulate Arc/Arg3.1 expression. PMID: 24810662
18. Arc mRNA was significantly decreased in the dorsal striatum of addiction vulnerable rats, and this reduction was restricted to the dorsomedial and not dorsolateral striatum. PMID: 25646592
19. Results showed that the expression of Arc, but not zif268, was significantly increased in the cerebellum following motor skill learning PMID: 25249385
20. BDNF activated the Arc proximal promoter, whereas class I histone deacetylases (HDACs) inhibited this activation. PMID: 25623071
21. Decreased expression of Arc and Egr-1 might be involved with instability of synaptic plasticity in tinnitus. PMID: 24704997
22. Deficits in Arc expression in the amygdala during alcohol withdrawal are reversed following treatment with HDAC inhibitors. PMID: 24103311
23. Collectively, these results suggest that Arc/Arg3.1 protein plays an important functional role in both the initial acquisition of hippocampal-dependent memory and the reconsolidation of these memories after recall. PMID: 23872190
24. NMDA- and dopamine D1 receptor-dependent Arc expression are important in reward-enforced, drug-seeking behavior. PMID: 23708554
25. The data of this study reveal a novel mechanism for controlling mRNA distribution within dendrites and highlight activity-dependent mRNA degradation as a regulatory process involved in synaptic plasticity. PMID: 24671994
26. findings suggest a link between motor cortex Arc expression and motor skill learning in rats PMID: 23876329
27. The retrieval of contextual memories increases Arc in the amygdala and hippocampus. PMID: 22945419
28. Our results demonstrate that the IEGs, egr1 and arc, may significantly contribute to synaptic reorganization induced by the kindling of seizures PMID: 23744421
29. Arc/Arg3.1 lateralization inversely correlates with taste familiarity in insular cortex. PMID: 23843540
30. Arg3.1 mediates the final stage of climbing fiber synapse elimination in the developing cerebellum. PMID: 23791196
31. Inner hair cell ribbon loss (deafferentation) leads to tinnitus when auditory brainstem response functions remain reduced and Arc is not mobilized. PMID: 23154938
32. This study demonistrated that isolation rearing alters ARC activation in the mPFC produced by exposure to a novel conspecific, in addition to changing social behavior, and that these effects depend in part on sex. PMID: 22982514
33. Arc protein expression is increased for over four hours in the hippocampus, demonstrating DNA methylation as a regulator of electroconvulsive stimulation (ECS)-induced gene expression. PMID: 22613772
34. Behavior-induced cell activity across the CA1 hippocampal axis uses Arc mRNA imaging methodology to compare and monitor adult and old rats in two different field remapping conditions. PMID: 23426670
35. Data from experimental model of developmentally-induced hypothyroidism suggest that hippocampus exhibits down-regulation of Arc and Egr1 (early growth response protein 1) compared with control; such mice exhibit deficits in spatial learning/memory. PMID: 23079472
36. Maze-running rats expressed Arc in more pyramidal cells than caged-controls. The pattern of Arc expression depended upon navigational strategy (place or response). PMID: 22573703
37. these data demonstrate a unique kinetic profile for Arc transcription in hippocampal granule neurons following behavior that is not observed in other cell types. PMID: 23345235
38. These observations imply the existence of a microdomain at the spine base where Arc mRNA docks in association with a previously unknown mRNA-binding structural element. PMID: 22350812
39. Arc is necessary for long-term memory formation of two types of learning tasks and is one of the PRPs that can be shared between them when animals are trained in both open field exploration and inhibitory avoidance. PMID: 22683463
40. Arc is regulated by multiple miRNAs and modulated by specific miRNA pairs in vitro PMID: 22844515
41. Arc signaling in the dorsomedial striatum is necessary for consolidation of reversal learning associated with a METH-induced change in neural substrates mediating such reversal learning. PMID: 22071872
42. Fewer granule cells in the aged fascia dentata transcribe arc 8 hours after spatial exploration; this decrease is correlated with impaired spatial memory. PMID: 20850902
43. neurons that were recently active during spatial exploration are preferentially recruited into further Arc expression during subsequent rest PMID: 22535445
44. Increased synaptic Arc/Arg3.1 expression contributes to aversive memory formation by regulating synaptic AMPA receptor (AMPAR) endocytosis. PMID: 22933785
45. analysis of dynamic, multifaceted control of Arc synthesis during mAchR signaling PMID: 22584581
46. These data suggest that cholinergic denervation of hippocampus leads to deficits in muscarinic-dependent induction of Arc and a subsequent impairment of spatial memory acquisition. PMID: 20865740
47. Arc transcription is reduced within the aged hippocampus compared to the adult hippocampus during both "off line" periods of rest, and following spatial behavior. PMID: 20189687
48. Study shows targeting of Arc to inactive synapses via a high-affinity interaction with CaMKIIbeta that is not bound to calmodulin. PMID: 22579289
49. the importance of intracellular mGluR5 in the cascade of events associated with sustained synaptic transmission PMID: 22179607
50. In CA1 there was a persistent increase in arc mRNA level during long-term potentiation, but during long-term depression, arc mRNA level first was decreased & then transiently increased relative to control level. PMID: 20824728

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KEGG: rno:54323

STRING: 10116.ENSRNOP00000063719

UniGene: Rn.10086