Recombinant Rat Angiotensin-converting enzyme(Ace) ,partial

Code CSB-YP001149RA
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Source Yeast
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Code CSB-EP001149RA
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Source E.coli
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Code CSB-EP001149RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001149RA
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Source Baculovirus
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Code CSB-MP001149RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ace
Uniprot No. P47820
Alternative Names
Ace; Dcp1; Angiotensin-converting enzyme; ACE; EC 3.2.1.-; EC; Dipeptidyl carboxypeptidase I; Kininase II; CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme; soluble form]
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
Gene References into Functions
  1. ascorbic acid is able to prevent hypertension in offspring from prenatal inflammation exposure through ACE1 downregulation PMID: 27995995
  2. Data suggest that angiotensin converting enzyme 1 within median preoptic nucleus plays a critical role in the sustained hypertension seen in chronic intermittent hypoxia. PMID: 28536140
  3. Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure. PMID: 28003214
  4. Pomegranate peel extract consumption conferred protection against hypertension in the spontaneously hypertensive rat model. This finding was demonstrated by marked reduction in coronary ACE activity, oxidative stress, and vascular remodelling. PMID: 27710705
  5. ACE inhibitor treatment could counteract glutamate neurotoxicity by preventing the downregulation of glutamate decarboxylase 2 (Gad2). Taken together, ACE inhibition targets neurodegeneration triggered by environmental stress. PMID: 26697495
  6. the relationship between ACE and ACE2 activity, left ventricular function and gender in spontaneously hypertensive rats, was determined. PMID: 26010093
  7. Finding suggests the involvement of microRNAs in the cardioprotective action of ACE inhibition in acute renal injury. PMID: 26400542
  8. Transient ACE inhibition can produce a persistent modification of the cardiac fibroblast phenotype to one that is less inflammatory and fibrogenic. PMID: 26371174
  9. ACE and ACE 2 are expressed in lipopolysaccharide-induced lung injury and rebalanced by ACE inhibitor captopril PMID: 25768373
  10. Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat. PMID: 25194129
  11. The study showed that both ACE and ACE-2 are overexpressed in the cardiac and renal tissues of animals with heart failure as compared with their sham controls. PMID: 25217176
  12. protein and beta-conglycinin may retard the progression of diabetic nephropathy by increasing insulin sensitivity, regulating lipid metabolism, improving renal function markers, and inhibiting ACE activity PMID: 25205218
  13. The increase in Ace mRNA levels was higher than that of Ace2 mRNA levels, leading to an elevated Ace/Ace2 ratio. PMID: 24781988
  14. ACE-inhibitory peptide LAP decreases blood pressure, inhibits smooth muscle cell hypertrophy and reduces the proliferation of collagen fibers. PMID: 23661144
  15. In the development of hypertension in diabetic rats, augmentation of circulating ACE activity precedes the sympathetic dysfunction. PMID: 23975725
  16. The results suggest that the gene silencing of intracellular ACE holds great potential in the treatment of cardiomyocyte apoptosis following ischemic reperfusion injury. PMID: 24126381
  17. study demonstrating that ACE shedding is regulated by NQO1 activation, which is possibly correlated with relieving hypertension in spontaneously hypertensive rats PMID: 23749777
  18. augmented tissue ACE activity in the coronary arterioles of obese subjects, which leads to reduced coronary dilation response to BK. PMID: 23603844
  19. Angiotensin converting enzyme gene expression is up-regulated in experimentally induced liver cirrhosis in rats. PMID: 24035938
  20. ACE downregulation by ACEI and ARB indicates that angiotensin II upregulates ACE through AT1 receptor PMID: 23733546
  21. Enalapril increases cardiac ACE levels in spontaneously hypertensive rats. PMID: 23706365
  22. Changes in the distribution of the ACE activity in aorta with increasing age in rat and by the action of L-NAME may play a role in development of atherosclerosis of aging vessels and inhibition of niric oxide formation. PMID: 21720771
  23. The expressions of ACE and ACE2 mRNA in lung tissue of the rats with paraquat poisoning are decreased. PMID: 20465954
  24. The Tc-Lis binds specifically to ACE, and the activity can be localized in Tg rat hearts that over-express human ACE-1 with a signal intensity that is sufficiently high to allow external imaging. PMID: 22498331
  25. culating angiotensin-converting enzyme decreased in diabetic females males PMID: 22378820
  26. The expression of VEGF, ACE, and MMP-9 mRNA levels in the resveratrol treated diabetic group decreased compared with values in the diabetic group. PMID: 22191573
  27. effect of inflammation on the expression levels of ACE and ACE-2 in two groups, adjuvant arthritis (AA) and healthy (control) rats. PMID: 21053061
  28. Local tissues from SHRs showed higher expressions of Ace1 mRNA and protein than those from the WKY rats. Ace1 promoter was mostly unmethylated in all of the tissues from both strains. PMID: 22311897
  29. ACEi, by moderating progenitor cell activation, restores glomerular architecture and prevents renal disease progression PMID: 21718676
  30. AngII infusion causes proteinuria-independent renal damage only in rats with genetically predetermined high ACE while rats with low ACE seemed to be protected against the detrimental effect of AngII. PMID: 21788250
  31. ACE expression and activity modifications are likely related to some of the physiological changes (cardiovascular, stress, cognition, metabolism function, water and energy balance) observed during and after sleep deprivation PMID: 21495912
  32. Suggest that elastase-2 may contribute as an alternative pathway for ANG II generation when ACE is inhibited in the rat vascular tissue. PMID: 21602471
  33. A vessel, organ and species specific pattern of distribution of endothelial ACE was observed (human vs. rat), providing an anatomical basis for organ and vessel specificity of the actions of the renin-angiotensin and kallikrein-kinin systems. PMID: 21167844
  34. Ang-(1-7) Mas receptors and AT2 receptors in hypothalamic paraventricular nucleus neurons play role in mediating tonic maintenance of renal sympathetic nerve activity. (Angiotensin 1-7) PMID: 16027241
  35. The attenuated counterbalancing effect of Ang-(1-7) on baroreflex function is lost in older rats, which may be attributable to diminished production of the peptide from neprilysin. (Angiotensin 1-7) PMID: 16009784
  36. Report the development of a stable and functional single-chain format of mAb 9B9 which specifically recognizes human and rat ACE represents a novel antibody-based reagent suitable for targeted delivery of drugs/genes to the pulmonary circulation. PMID: 20888351
  37. Treatment with the tissue specific ACE inhibitor quinapril revealed an important microvascular improvement, especially at arteriolar level. PMID: 20570682
  38. during mechanical ventilation ACE, via Ang II, mediates the inflammatory response of both healthy and preinjured lungs PMID: 20304959
  39. SMC and EC have a pathway for delivery of extracellular ACE to the nucleus, most likely involving cell surface receptor(s) and requiring transit through late endosome/lysosome compartments. PMID: 20022959
  40. The greater cardiac fibrosis in Brown Norway rats treated with isoproterenol correlates with the early and higher expression of proinflammatory factors. PMID: 18957386
  41. Nitric oxide synthase mRNA levels do not correlate with gene expression of angiotensin converting enzyme in selected brain areas. PMID: 11702851
  42. Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model. PMID: 11875308
  43. Data show that angiotensin converting enzyme inhibition decreases cell turnover in the developing rat heart, which may contribute to cardiac growth impairment. PMID: 12193663
  44. results demonstrated that the rodent germinal angiotensin converting enzyme is released from the testicular sperm membrane when sperm enter the epididymis PMID: 12444051
  45. higher renal ACE activity is associated with more severe renal damage for a given amount of proteinuria, suggesting that renal ACE activity may be either a permissive or a promoting factor in the processes by which proteinuria leads to renal damage. PMID: 12806593
  46. Rats in the F(2) generation with high plasma ACE activity developed more fibrosis but to a similar degree of left ventricular hypertrophy compared with rats with low plasma ACE activity. PMID: 14527934
  47. activation of the enzymatic activity of ACE, the critical enzyme for determining the conversion of angiotensin I into the physiologically active angiotensin II, by chronic hypoxia in the carotid body. PMID: 14527966
  48. Binding increased in subfornical organ, organum vasculosum laminae terminalis, paraventricular nucleus, and median preoptic nucleus. In heart, greatest increase occurred at infarct scar and least in right ventricle. PMID: 14693687
  49. Identification of shear stress responsive elements in the angiotensin I converting enzyme promoter. PMID: 14872008
  50. TGF-beta 1 expression is correlated with ACE expression and could be a link between ACE gene polymorphism and diabetic vascular complications. PMID: 15047629

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Subcellular Location [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein Families Peptidase M2 family
Tissue Specificity Testis-specific isoform is expressed in spermatocytes, adult testis. Also expressed in brain, kidney, lung, skeletal muscle and heart.
Database Links

KEGG: rno:24310

STRING: 10116.ENSRNOP00000010627

UniGene: Rn.10149

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