Recombinant Rabies virus Glycoprotein (G)

1. results demonstrate that G-mediated dendritic cell activation is regulated by the ectodomain while the level of G expression by the cytoplasmic tail domain PMID: 28161580
2. Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants has been described. PMID: 27132040
3. Data suggest that two copies of the glycoprotein gene could be a potential candidate in the development of novel inactivated rabies vaccines. PMID: 24498294
4. N-glycosylation at position 37, but not at position 146 of G protein reduces pathogenicity. PMID: 24177272
5. G proteins lacking an N-glycan at Asn(319) failed to fold into their correct structure and lost their fusion activity, indicating that Asn(319) N-glycosylation is important for the functional expression of street virus G proteins. PMID: 23114627
6. human PCBP2 specifically and selectively interacts with rabies virus glycoprotein mRNA and this interaction may contribute to the post-transcriptional regulation of glycoprotein expression PMID: 22438951
7. N-glycosylation sites in the G protein is one of the determinants of the pathogenicity of rabies virus. PMID: 22248643
8. The authors conclude that the expression level of the glycoprotein gene does have an impact on pathogenicity but is not a dominant factor that determines pathogenicity. PMID: 21068252
9. R333Q mutation in the G protein is crucial for the attenuation of Flury rabies virus in mice. PMID: 20538851
10. attenuation of rabies virus requires expansion of the set of host PDZ proteins with which G interacts, which interferes with the finely tuned homeostasis required for survival of the infected neuron PMID: 20086240
11. Amino acid substitutions of G protein affect efficiency of cell-to-cell spread but not apoptosis-inducing ability. PMID: 20377742
12. concluded that functional maturation of G protein to acquire fusogenic activity is correlated with 1-30-44 epitope formation PMID: 15557743
13. trimerization is required for efficient interaction with p75NTR PMID: 16099913
14. results presented here show that at least three amino acids at positions 242, 255 and 268 of the G protein are essential for the pathogenicity of the Nishigahara strain PMID: 16188341
15. We confirmed that an arginine at position 333 in G protein contributed to reversion of the pathogenicity in a highly attenuated HEP-Flury strain of rabies virus. PMID: 16473429

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KEGG: vg:1489856