Human Insulin,INS ELISA Kit

Code CSB-E05069h
See More Details 24T ELISA kits trial application
Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P01308
Lead Time 3-5 working days
Protein Biological Process 2 glyconeogenesis and glycometabolism
Abbreviation INS
Protein Biological Process 1 Metabolism
Target Name insulin
Alias ILPR, IRDN, OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
Species Homo sapiens (Human)
Protein Biological Process 3 Carbohydrate metabolism
Sample Types serum, plasma, cell culture supernates, tissue homogenates
Detection Range 10 μIU/mL-100 μIU/mL
Sensitivity 2 μIU/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Metabolism
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Assay Principle quantitative
Measurement Sandwich
Target Details After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region.
HGNC 3818
RGD 61807
MGI 1347487
References
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Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Involvement in disease Hyperproinsulinemia (HPRI); Diabetes mellitus, insulin-dependent, 2 (IDDM2); Diabetes mellitus, permanent neonatal (PNDM); Maturity-onset diabetes of the young 10 (MODY10)
Subcellular Location Secreted
Protein Families Insulin family
Database Links

HGNC: 6081

OMIM: 125852

KEGG: hsa:3630

STRING: 9606.ENSP00000250971

UniGene: Hs.272259

Pathway HIF-1 signaling pathway
MAPK signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Autophagy
Ras signaling pathway
AMPK signaling
cGMP-PKG signaling pathway
FoxO signaling pathway
Insulin signaling pathway
Phospholipase D signaling pathway
Rap1 signaling pathway

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