SRC Antibody

Datasheet
Code CSB-PA022650XA01CH
Product Type Polyclonal Antibody
Uniprot No. P00523
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Gallus gallus (Chicken) SRC protein
Raised in Rabbit
Species Reactivity Gallus gallus (Chicken)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC
Immunogen Species Gallus gallus (Chicken)
Gene Names SRC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus
Subcellular Location Cell membrane, Mitochondrion inner membrane, Endosome membrane, Peripheral membrane protein, Nucleus, Cytoplasm, cytoskeleton, Cytoplasm, perinuclear region
Protein Families Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Tissue Specificity Expressed to high levels, and with a high degree of kinase activity, in certain fully differentiated cells such as neurons, platelets and macrophages. Isoform 1 is widely expressed. Isoform 2 is expressed only in the muscle.
Database Links

KEGG: gga:396442

STRING: 9031.ENSGALP00000006117

UniGene: Gga.46254

Pathway Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Adherens junction
Mitophagy
Rap1 signaling pathway
Endocytosis
Excitatory synapse pathway

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