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| Code | CSB-EP318401LNPe1 |
| Product Type | Recombinant Protein |
| Size | US$2632 |
| Uniprot No. | P13699 |
| Relevance | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Species | Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Sequence | MSASKEIKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKERRDDNDLKRLRDLNQAVNNLVELKSTQQKSILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGMSGGNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTSDLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETIKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYENILYKICLSGDGWPYIASRTSITGRAWENTVVDLESDGKPQKADSNNSSKSLQSAGFTAGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDSRKYENAVWDQYKDLCHMHTGVVVEKKKRGGKEEITPHCALMDCIMFDAAVSGGLNTSVLRAVLPRDMVFRTSTPRVVL |
| Research Area | Microbiology |
| Source | E.coli |
| Gene Names | N |
| Protein Names | Nucleocapsid protein Protein N |
| Expression Region | 1-569aa |
| Tag Info | Tag-Free |
| Mol. Weight | 63.0 kDa |
| Protein Description | Full Length |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). |
| Subcellular Location | Virion, Host cytoplasm |
| Protein Families | Arenaviridae nucleocapsid protein family |
| Database Links |
KEGG: vg:956584 |
N Antibodies for Lassa virus
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA318401LC01LNP | N Antibody, FITC conjugated | Lassa virus | ELISA |
| CSB-PA318401LB01LNP | N Antibody, HRP conjugated | Lassa virus | ELISA |
| CSB-PA318401LA01LNP | N Antibody | Lassa virus | ELISA |
| CSB-PA318401LD01LNP | N Antibody, Biotin conjugated | Lassa virus | ELISA |
N Proteins for strain Mouse/Sierra Leone/Josiah/1976)(LASV)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP318401LNP | Recombinant Lassa virus Nucleoprotein(N) | Yeast |
N Proteins for Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP318401LNP | Recombinant Lassa virus Nucleoprotein(N) | E.coli |
| CSB-BP318401LNP CSB-MP318401LNP |
Recombinant Lassa virus Nucleoprotein(N) | Baculovirus Mammalian cell |
Recombinant Human Proteasome subunit beta type-10(PSMB10)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial
Express system: Yeast
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Recombinant Human Translation initiation factor eIF-2B subunit beta(EIF2B2)
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Recombinant Human Myeloid leukemia factor 1(MLF1)
Express system: E.coli
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Recombinant Human Visinin-like protein 1(VSNL1)
Express system: E.coli
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Recombinant Human Receptor-type tyrosine-protein phosphatase C(PTPRC),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Integrin alpha-IIb(ITGA2B),partial
Express system: E.coli
Species: Homo sapiens (Human)
