Currently, targeted therapy is an effective method for cancer, which presents instinct advantages over chemical therapy. However, the appropriate selection of drug targets is the key to the success in cancer therapy.
Accurate identification of drug targets is a crucial part of any drug development program. So-called drug targets, we usually refer to a series of protein, and they are also known as drug target protein. The development of this drugs aims to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation.
The most common drug target proteins include three types, involving CD antigen, FC receptor and immune checkpoint.
Here, based on cancer databases and latest researches of cancers, we collect the hot targets of six cancer, including breast cancer, lung cancer, thyroid cancer, prostate cancer, stomach cancer and ovarian cancer. Additionally, we compile the latest development of drug targets in clinic application, and related signaling pathways. We hope these information will give you some inspiration in cancer therapy.
Popular Drug Target Proteins In CUSABIO
To accelerating drug development, CUSABIO has developed a large number of active proteins for various drug targets. These proteins can be used in ELISA, immunization, SPR. Please click the following targets to know more...
Cancer Drug Targets
● Breast Cancer
Breast cancer is a cancer that develops in the tissues of breasts. In the United States, breast cancer is a cancer that is ubiquitous in women, second only to skin cancer. Actually, breast cancer can occur in both men and women, but it's far more common in women.
Supported for breast cancer awareness prevalence and accumulating research funding has helped created advances in the diagnosis and treatment of breast cancer. Breast cancer survival rates have increased, and the number of deaths associated with this disease is steadily declining.
Further reading:
The Overview of Breast Cance
The article contains the related signaling pathways and therapeutic targets of breast cancer.
Moreover, you may also check breast cancer signaling pathway here.
Additionally, we have compiled popular targets related to breast cancer based on cancer databases and recent research. These targets are shown as follows:
● Lung Cancer
Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale.
In the U.S., lung cancer is the common cause of cancer deaths in both men and women, even in worldwide. It claims more lives each year than do colon, prostate, ovarian and breast cancers combined, and the cause of lung cancer is still not completely clear. For this reason, the pathogenesis and treatment of lung cancer has always been the focus of research by researchers.
Further reading:
What You Have to Know about Lung Cancer.
This article introduces the symptoms and types of lung cancer in details. These information will help you to get to know this disease better.
Here, we have compiled popular targets related to lung cancer based on cancer databases and recent research. These targets are shown as follows:
● Thyroid Cancer
As you know, thyroid is shaped like a small butterfly, and is usually found inside the lower front of your neck. It plays a critical role in regulating your metabolism. Moreover, it also releases hormones that direct many functions in your body, including the use of energy, heat production, and oxygen consumption. When it comes to pathological changes, the whole functions of your body are impacted.
Thyroid cancer is a typical cancer that develops from the tissues of the thyroid gland. It is a disease in which cells have undergone genetic mutation and grow abnormally. This disease also has the potential to spread to other parts of the body.
Further reading:
About Thyroid Tumor, This Information You Must Know!
This article introduces the symptoms and types of thyroid tumor in details. These information will help you to know it better.
Currently, there is no clear reason why most people get thyroid cancer. Here, we have compiled popular targets related to thyroid cancer based on cancer databases and recent research. We hope there information would give you inspiration of thyroid cancer research. These targets are shown as follows:
● Prostate Cancer
Prostate gland is a part of the male reproductive system that plays a role in semen production. Prostate cancer develops when the prostate cells undergo genetic changes. It is the most common malignancy among men (after skin cancer) and the cause of 1-2% of deaths in men. This disease can last several years or be lifelong. But, fortunately, it can often be treated successfully.
Here, we have compiled popular targets related to prostate cancer based on cancer databases and recent research. These targets are shown as follows:
● Stomach Cancer
Stomach cancer, also called gastric cancer, begins when cancer cells form in the inner lining of your stomach. These cells can grow into a tumor. The disease usually grows slowly over many years. This cancer is one of the most common malignant tumors worldwide.
According to statistics from the latest data, 876,000 new cases of gastric cancer occur every year in the world, accounting for 9% of all new cancer cases, and ranking fourth after lung cancer, breast cancer and intestinal cancer.
As mentioned, this disease usually grows slowly over many years. In other words, the cancer may not cause any signs or symptoms or it may cause only nonspecific symptoms in its early stages because the tumor is small.
Further reading:
The Overview of Gastric Cancer
This article collects the symptoms of early stage and advanced stomach cancer.
Additionally, we have compiled popular targets related to stomach cancer based on cancer databases and recent research. These targets are shown as follows:
● Ovarian Cancer
Ovarian cancer is a type of cancer that forms in the ovaries. It causes by abnormal cell that have the ability to invade or spread to other sections of your body.
Generally, the female reproductive system contains two ovaries, one on each side of the uterus. The ovaries produce eggs (ova) as well as the hormones estrogen and progesterone.
Similar as stomach cancer, ovarian cancer often goes undetected until it has spread within the pelvis and abdomen. But this time is the late stage of ovarian cancer. At this stage, ovarian cancer is more difficult to treat. However, early-stage ovarian cancer is usually confined to the ovary and more likely to be treated successfully.
Further reading:
Ovarian Cancer -- The Silent Killer
This article introduces the symptoms and types of ovarian cancer in details. These information will help you to know it better.
Here, we have compiled popular targets related to ovarian cancer based on cancer databases and recent research. These targets are shown as follows:
The latest Drug Research
Based on the latest drug research progression, we summarize the latest drug research of hot drug targets.
Target | Marketed Drugs | Development Drugs | Latest Phase | Indication |
---|---|---|---|---|
CTGF | 0 | 1 | Phase III | Pancreatic Cancer; Duchenne Muscular Dystrophy; Idiopathic Pulmonary Fibrosis |
CD160 | 0 | 3 | Preclinical | Autoimmune Disorders; Eye Disorders; Age-Related; Macular Degeneration; Aspergillosis; Chronic Lymphocytic Leukaemia |
CD19 | 2 | 98 | Marketed | Leukaemia; Lymphoma |
CD40 | 0 | 18 | Phase I/II | Cervical Cancer; Head And Neck Cancer; Penile Cancer; Solid Tumors; Autoimmune Disorders; Inflammation |
CD47 | 0 | 14 | Phase I | Haematological Malignancies; Solid Tumors; Breast Cancer; Non-Hodgkin's Lymphoma; Acute Myeloid Leukaemia; Myelodysplastic Syndromes; Mycosis Fungoides; Sezary Syndrome; Small Cell Lung Cancer |
CD86 | 0 | 3 | Preclinical | Autoimmune Disorders; Cancer; Graft-Versus-Host Disease; Irritable Bowel Syndrome; Rheumatoid Arthritis; Graft-Versus-Host Disease; Irritable Bowel Syndrome; Rheumatoid Arthritis |
CD8A | 0 | 1 | Preclinical | Cancer; Precursor Cell Lymphoblastic Leukaemia-Lymphoma; Solid Tumors |
CTLA4 | 3 | 13 | Marketed | Inflammation; Autoimmune Disorders; Rheumatoid; Arthritis; Cancer; Transplant Rejection; Malignant Melanoma; Renal Cell Carcinoma; Juvenile Rheumatoid Arthritis; Psoriatic Arthritis; Renal Transplant Rejection |
DLL3 | 0 | 4 | Preclinical | Small Cell Lung Cancer; Solid Tumors; Acute Myeloid Leukaemia; Haematological Malignancies |
EGFR | 7 | 61 | Marketed | Colorectal Cancer; Head And Neck Cancer; Non-Small Cell Lung Cancer; Solid Tumors |
FSHR | 0 | 1 | Preclinical | Amyotrophic Lateral Sclerosis; Autistic Disorder; Charcot-Marie-Tooth Disease; Fragile X Syndrome; Polycystic Ovary Syndrome; Visceral Pain |
HAVCR2 | 0 | 1 | Preclinical | Acute Myeloid Leukaemia; Haematological Malignancies; Multiple Myeloma |
MS4A1 | 3 | 42 | Marketed | Haematological Malignancies; Lymphoproliferative Disorders; Non-Hodgkin's Lymphoma; B-Cell Lymphoma; Chronic Lymphocytic Leukaemia; Diffuse Large B Cell Lymphoma; Follicular Lymphoma; Granulomatosis With Polyangiitis; Idiopathic Thrombocytopenic Purpura; Microscopic Polyangiitis; Nephrotic Syndrome; Pemphigus Vulgaris; Rheumatoid Arthritis |
MYC | 0 | 11 | Phase III | Cancer; Infections; Candidiasis; Cryptococcosis; Haematological Malignancies |
REL | 0 | 7 | Preregistration | Bacterial Infections; Neuropathic Pain; Diabetic Neuropathies; Eye Disorders; Intra-Abdominal Infections; Urinary Tract Infections; Major Depressive Disorder; Pneumonia |
SIRPA | 0 | 5 | Phase I | Cancer; Lymphoma; Multiple Myeloma |
TNFRSF14SIRPA | 0 | 1 | Preclinical | Solid Tumors |
TNFRSF17 | 0 | 27 | Phase III | Multiple Myeloma; Solid Tumors; Acute Myeloid Leukaemia |
TNFRSF9 | 0 | 10 | Phase II | Solid Tumors; Glioblastoma; Multiple Myeloma; Non-Hodgkin's Lymphoma 2; Autoimmune Disorders |
TTR | 1 | 4 | Marketed | Amyloidosis; Amyloid Polyneuropathy; Cancer; Cardiomyopathies |
Related Signaling Pathways
Here, we present the top 19 cancer-related signaling pathways. Besides, you may be interested in the other signaling pathway, you can click the following link to view the full signaling pathway: https://www.cusabio.com/pathway.html.
Predicted Functional Partners
Additionally, according to the data from STRING (https://string-db.org/), we collect the predicted functional partners of the hot drug targets respectively. Each hot drug target and their predicted functional partners are shown as follows: