Predicted Functional Partners

Additionally, according to the data from STRING (https://string-db.org/), we collect the predicted functional partners of the hot drug targets respectively. Each hot drug target and their predicted functional partners are shown as follows:

KCNN4 KCNMA1, KCNMB4, CALM1, CALM3, KCNK5, KCNU1, KCNMB1, PHPT1
LGR5 RSPO1, RNF43, ZNRF3, RSPO2, RSPO3, RSPO4, UBC, LGR4, LGR6, UBB
C3 CFH, CD46, CR1, CF1, CD55, CR2, CFD, ITGAM
MYC KAT2A, SUPT3H, MAX, MED1, MED16, CDKN2A, AKT1, JUN, BIN1
CD8A CD8B, LCK, CD4, HLA-A, CD3D, IL2, IL2RB, CD3G, HLA-C
TP53 MDM2, MDM4, BCL2L1, CREBBP, ATM, CDKN1A, TP53BP2, CHEK2, CDKN2A
GSTP1 PRDX6, EPHX1, GSTT2B, GGH, CYP1A1, GSTO1, STO2, CYP2E1, CYP1B1, TRAF2
APOE LDLR, APOB, APOC2, APOC1, APOA1, LRP8, APOA2, APOC3
ELANE SLPI, DEFA4, CTSG, BPI, CAMP, AZU1, MMP8, GRN
HLA-E KLRC1, KLRD1, KLRC2, LILRB1, HLA-G, HLA-F, HLA-C, HLA-B, TAPBP
HLA-G LILRB2, LILRB1, KIR2DL4, HLA-F, HLA-A, HLA-C, HLA-E, HLA-B, CD8A
NCL NPM1, WDR43, NOP56, NOP58, WDR46, RPS6, HSP90AA1, WDR75
MS4A1 MS4A3, CD19, CD79A, CD79B, MS4A7, FCER2, IGLL5, FCRLA, CD22, IGHV3-11
TRIM21 TROVE2, IRF7, DDX41, IRF3, IRF5, UBE2D2, PML, HLA-DRB1, SP100
FSHR TSHB, LHB, GPHB5, GPHA2, INSL3, MC4R, AVPR2
GUCY2C GUCA2B, ITPA, NUDT2, PDE5A, PDZD3, GLYAT, GGCT, DOCK11, AGA
TEAD1 YAP1, WWTR1, TEAD2, TEAD4, VGLL4, CTGF, VGLL1, VGLL3, VGLL2, TEAD3
CTGF TGFB1, YAP1, WWTR1, TEAD4, TGFB3, TEAD1, TGFBR2, FN1, TEAD2, TEAD3
YAP1 TEAD4, LATS1, SMAD7, TEAD1, TEAD2,TEAD3, LATS2, ERBB4, CTGF, AMOTL1
RORC STAT3, FOXP3, STAT6, IL17A, MED1, TBX21, NCOA1, RORB, NCOR2, NRIP1
FOLH1 RIMKLB, RIMKLA, ASPA, NAT8L, PSCA, DPP4, EGFR, SMUG1, AR
REL NFKBIA, NFKBIB, NFKB1, NFKBIE, RELA, IKBKG, CHUK, IKBKB, CARD11
Ly75 ITGAX, CD207, CLEC9A, CD86, CD40, CD209, CD80, CLEC4A, ITGAM, ITGAE
TTR APCS, ORM2, STRA6, C3, RBP1, HSPG2, VCP, LYZ
CLEC4C ITGAX, SLC2A3, ITGAM, CD33, FCER1G, CEACAM8, LILRB2, SIRPA, CD300A, FCAR
IFIH1 MAVS, IRF7, IRF3, DDX58, TBK1, IKBKE, TRIM25, NLRC5, RNF125, IFIT1
DLL3 NOTCH1, JAG1, DLL1, NOTCH3, DLL4, HES7, MESP2, LFNG, NOTCH4
EGFR >EGFGRB2, SHC1, CBL, KRAS, TGFA, STAT3, EREG, HRAS
TNFRSF17 Tnfsf13b, Tnfsf13, Tnfrsf13b, Tnfrsf13c
CD160 HLA-C, HLA-G, HLA-E, HLA-A, HLA-F, HLA-B, TNFRSF14, LAG3, BTLA
CD19 CD79A, CR2, LYN, CD79B, CD81, VAV1, SYK, BTK, BCL6, IGLL5
CD40 TAB2, TRAF6, TLR3, TNF, TAB1, MAP2K6, IKBKG, TAB3, MYD88, EIF2AK2
CD40LG CD40, TNF, TNFSF13B,TRAF1 , STAT5A, ITGAM, TNFRSF13C, TRAF2, BIRC2, TRAF3
CD47 SIRPA, SIRPG, THBS1, ITGAV, CLEC12A, ITGAM, THBS2, CD59, ITGB3
CD86 CTLA4, CD28, IL10, CD80, CD83, CD3E, CD40, ITGAX, HLA-DRB1, STAT3
CTLA4 CD86, CD80, FOXP3, LCK, FYN, ITGA4, ICOSL, ITGAL, IL17A
FCGR3A FCGR3B, FCGR1A, HCK, FCER1G, SYK, LILRB2, FGR, CD2, FCGR2A, IGLL5
HAVCR2 LGALS9, LAG3, CEACAM1, CTLA4, IL2, CD274, TBX21, FOXP3, PDCD1, CD160
LAMP1 WDR24, NPRL2, NPRL3, WDR59, SZT2, CD63, NCSTN, VAMP8, RAB5C, ATP6V0C
NECTIN2 CD226, TIGIT, MLLT4, PVRL3, PVRL4, CDH1, CRTAM, PVRL1, CTNNB1, CTNNA1
>NT5E ADA, ADK, ENTPD1, PNP, TYMP, CDA, ENG, APRT, DUT
SIRPA CD47, PTPN6, ITGAM, ITGAX, SIRPG, CD300A, FYB, CLEC5A, CD33
TNFRSF14 BTLA, TNFSF14, LTA, TRAF1, TRAF5, PTPN6, TRAF2, TRAF3, CD160
TNFRSF4 TNFSF4, CTLA4, CD28, TNFRSF18, IL2, TNF, FOXP3, IL4s, TRAF5, TRAF3
TNFRSF9 TNFSF9, TRAF2, MAP3K5, CTLA4, IL2, TMEM26, TNF, IL15, CD28, CARTPT
TNFSF4 TNFRSF4, IL10, ATM, TSLP, TNFSF9, IL33, CD70, CD40, ICOSL

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