Recombinant Mouse Tyrosine-protein kinase Tec (Tec)

1. Results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 macrophages cells via NF-kappaB pathway. PMID: 28415764
2. these data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase. PMID: 28275136
3. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. PMID: 25993510
4. identify dectin-1 as the pathogen recognition receptor being required for Syk-dependent Tec activation. PMID: 25474208
5. Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific. PMID: 26026062
6. Tec kinase can act as a prosurvival factor and is regulated by IGF-I in human neutrophils through PI(3)K activation. PMID: 23261945
7. TEC promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor-induced Erk signaling pathway. PMID: 21094130
8. our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations. PMID: 20870948
9. These experiments expand the role of the Tec family in the heart, identifying the Tec isoform as an ischemic injury-induced isoform PMID: 20543088
10. the absence of the Tec family kinase Itk, which regulates the production of Th2 cytokines, leads to resistance in the C57BL/6 background, but decreases susceptibility on the BALB/c background PMID: 20596543
11. Tec kinase has a crucial role in regulating FGF2 secretion under various physiological conditions PMID: 20230531
12. Our results demonstrate a crucial role for Tec PMID: 19688741
13. Data demonstrate that NF-kappaB is an essential transcription factor for optimal expression of the Tec gene, and identify a unique functionally active NF-kappaB binding site in its promoter. PMID: 19843184
14. results demonstrate an essential requirement for Tec and Btk in platelet activation by GPVI and reveal a functional role for Tec in the regulation of PLC gamma 2 in the absence of Btk PMID: 12842985
15. Tec overexpression in lymphocyte cell lines is sufficient to induce phospholipase Cgamma (PLC-gamma) phosphorylation and NFAT (nuclear factor of activated T cells) activation. PMID: 14993283
16. a novel PKCtheta-initiated pathway that regulates Ca(2+) signaling and AP-1 activation via Tec and PLCgamma1 PMID: 15214048
17. Tec vesicles have a membrane proximal location and overlap with the tyrosine kinase Lck, the Tec substrate PLC-gamma1, and the early endosomal antigen 1 marker EEA1 PMID: 15817477
18. A role for Tec kinase is demonstrated in CD8+ T cell signaling and function both in vitro and in vivo. PMID: 16424186
19. Study reports that mice lacking the tyrosine kinases Btk and Tec show severe osteopetrosis caused by a defect in bone resorption. PMID: 18329366
20. Tec regulates macrophage colony-stimulating factor receptor (M-CSFR) signaling-induced macrophage survival; this study provides a link between Tec family kinases, regulation of caspase-11, and expression of the granulocyte-macrophage-CSFR alpha chain. PMID: 18523268
21. Tec family kinases participate in at least two stages of FcgammaR-mediated phagocytosis: activation of Mac-1 during ingestion, and after phagosome formation, during which Btk and Tec potentially have distinct roles PMID: 18566394
22. Tec kinase could significantly enhance IL-8 transcription. PMID: 19507016

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KEGG: mmu:21682

STRING: 10090.ENSMUSP00000071836

UniGene: Mm.319581