Recombinant Mouse Myeloperoxidase (Mpo)

1. Severe clinical and pathological disease is associated with the induction of anti-MPO IgG/LPS-mediated glomerulonephritis. PMID: 28186568
2. These studies further support involvement of MPO-catalyzed oxidative processes in both the development of atherosclerosis and diabetes risk PMID: 28069522
3. Neutrophils are abundant in abdominal aortic aneurysm (AAA), and myeloperoxidase (MPO), prominently expressed in neutrophils, is associated with AAA. taurine, which can scavenge MPO-generated oxidants, can prevent AAA formation. PMID: 28971841
4. PTX3 attenuates the production of murine myeloperoxidase-anti-neutrophil cytoplasmic antibody induced by aluminum salt adjuvant. PMID: 28850023
5. There is a smaller number of MPO positive neutrophils in the inflammatory infiltrate of a resistant model of amoebic liver abscess. PMID: 28796788
6. thisa study shows that neutrophil myeloperoxidase plays a paradoxical role in bacterial clearance and tissue damage in pneumococcal acute otitis media PMID: 28359218
7. lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co PMID: 26949091
8. MPO deficiency upregulates the expression of several proinflammatory cytokines and chemokines in mouse neutrophils PMID: 26573963
9. Myeloperoxidase may be an important determinant of diet and inflammation on colon cancer risk via its effect on endogenous exposure to oxidants and acrolein. PMID: 26262998
10. Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. PMID: 25885273
11. ethanol catabolism in renal tubules results in a self-perpetuating cycle of CYP2E1 induction, local PTAFR ligand formation, and neutrophil infiltration and activation that leads to myeloperoxidase-dependent oxidation and damage to kidney function. PMID: 26003521
12. These findings suggest that myeloperoxidase may contribute importantly to formation and rupture of CA. PMID: 25922506
13. Myeloperoxidase binds to RBC membranes in vitro and in vivo, is transported by RBCs to remote sites, and affects endothelial function as well as systemic vascular resistance. PMID: 24976018
14. MPO knockout mice were protected from high fat diet-enhanced body weight gain and insulin resistance. Lack of MPO also attenuated HFD-induced macrophage infiltration and expression of proinflammatory cytokines. PMID: 25024373
15. these results demonstrate that MPO deficiency ameliorates renal injury in the renal ablation model of chronic kidney disease in mice. PMID: 24990898
16. MPO contributes to the development of arthritis despite suppressing adaptive immunity in secondary lymphoid organs. This suggests distinct effects of local MPO on arthritogenic effector responses. PMID: 24757143
17. data suggest that the conversion of exogenous HE to 2-Cl-E(+) may be a useful selective and sensitive marker for MPO activity in addition to 3-Cl-Tyr. PMID: 24436331
18. the role of leukocyte activation, leukocyte-derived MPO and MPO-generated oxidants on BBB function PMID: 23691142
19. Data suggest that expression of Mpo in kidney is significantly correlated with severity of kidney damage in a mouse model of type 2 diabetes. PMID: 23268804
20. Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. PMID: 23686858
21. Data indicate that myeloperoxidase-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) induces injury via both humoral and cell mediated immune mechanisms. PMID: 23665205
22. The role of genetics in myeloperoxidase -antineutrophil cytoplasmic autoantibodies necrotizing and crescentic glomerulonephritis severity was investigated using 13 inbred mouse strains. PMID: 23384999
23. MPO, via its catalytic activity, inhibits the generation of adaptive immunity by suppressing dendritic cell activation, antigen uptake/processing, and migration to lymph nodes to limit pathological tissue inflammation. PMID: 23509155
24. ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase during inflammation PMID: 23306200
25. The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis. PMID: 22955884
26. MPO exacerbated secondary injury and impaired the functional recovery by generating strong oxidant HOCl, and enhancing neutrophil infiltration after spinal cord injury. PMID: 22322369
27. Results provide evidence for the participation of myeloperoxidase (MPO) - one of the key-orchestrators of inflammatory response. PMID: 22479306
28. The present study suggests that myeloperoxidase-mediated OCl(-) generation affects claudin molecules and leads to protein leakage and viral spread as a damage factor in influenza-induced acute respiratory distress syndrome. PMID: 22211924
29. Green tea extract attenuates NADPH oxidase activity and the expression of myeloperoxidase and inducible nitric oxide synthase in ob/ob mice, thereby suppressing oxidative and nitrative modifications that otherwise lead to liver injury. PMID: 21543212
30. MPO has dual functionality under rotenone-exposed conditions, playing a critical regulatory role in modulating pathological and protective events in the brain PMID: 21704008
31. MPO is susceptible to the free radicals it generates, and this Achilles' heel of the enzyme can be exploited to block oxidative stress during inflammation. PMID: 21880720
32. Rosiglitazone inhibits MPO secretion in RAW264.7 cells. PMID: 19778788
33. Given MPO's affinity to both the endothelial and the leukocyte's surface, MPO evolves as a mediator of PMN recruitment because of its positive surface charge. PMID: 20980678
34. Data indicate that myeloperoxidase contributes to the reduced reverse cholesterol transport observed during acute phase responses. PMID: 20061576
35. myeloperoxidase is responsible for protein nitration and cardiomyocyte apoptosis in nonlethal traumatic mice. PMID: 20153732
36. Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO-ANCA production. PMID: 11831441
37. MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida. PMID: 12085336
38. MPO was observed to modulate the vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation PMID: 12089442
39. Data show that myeloperoxidase and plasminogen activator inhibitor 1 play a critical role in the left ventricular response immediately after myocardial infarction. PMID: 12615902
40. the MPO/H2O2 system has a role in up-regulating the catalytic activity of iNOS that occurs at sites of inflammation PMID: 14657339
41. In knockout mice, suppressed MPO-derived oxidative/nitrative stress is associated with enhanced lung inflammation and persistent alveolar epithelial injury. PMID: 15020295
42. Role of MPO in cellular immunity to fungi and bacteria in MPO knockout and chronic granulomatous disease mice. PMID: 15507755
43. Compelling evidence is provided that susceptibility to infection with Gram-negative Klebsiella pneumoniae is enhanced in myeloperoxidase-deficient mice. PMID: 15661916
44. mechanical loading activates neutrophil-mediated lysis of muscle cells through an MPO-dependent pathway PMID: 15790660
45. aberrant MPO-antineutrophil cytoplasmic autoantibody production was exclusively controlled by Man-1 PMID: 16517735
46. data suggest a major role of myeloperoxidase in the immunological defence to Cryptococcus neoformans infection PMID: 16914663
47. myeloperoxidase is regulated by LXR and PPARalpha ligands PMID: 16956579
48. Along with the activation of AMPD3, ischemia-reperfusion-induced lung inflammation is associated with increased MPO activity and TNF-alpha level. PMID: 17384464
49. These results are consistent with the notion that nitric oxide and MPO contribute in liver tissue lipid peroxidation in peritonitis. PMID: 17901846
50. blood myeloperoxidase is increased and myeloperoxidase-positive neutrophils develop in atherosclerotic lesions in LDLR-/- mice PMID: 17991873

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KEGG: mmu:17523

STRING: 10090.ENSMUSP00000020779

UniGene: Mm.4668