Rat cartilage oligomeric matrix protein,COMP ELISA Kit

Code CSB-E13833r
Size 96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name cartilage oligomeric matrix protein
Alternative Names CompCartilage oligomeric matrix protein ELISA kit; COMP ELISA kit
Abbreviation COMP
Uniprot No. P35444
Species Rattus norvegicus (Rat)
Sample Types serum, plasma, tissue homogenates
Detection Range 78 pg/ml - 5000 pg/ml
Sensitivity 19.5 pg/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cell Biology


Typical Data  
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Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Data

Function May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Gene References into Functions
  1. COMP could normally have a protective role against PASMC phenotype switching PMID: 28860005
  2. these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence. PMID: 27498005
  3. COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways PMID: 25446117
  4. results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age PMID: 23850469
  5. The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis. PMID: 22154936
  6. Cartilage oligomeric matrix protein is a novel inhibitor of vascular smooth muscle calcification. PMID: 21350216
  7. Overexpression of COMP markedly suppressed PDGF-BB-elicited VSMC dedifferentiation. Alpha(7)beta(1) integrin is a potential receptor for COMP. PMID: 20019333
  8. Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin. PMID: 12225811
  9. The X-ray structure of the COMP coiled coil domain in complex with vitamin D(3) at 1.7 A resolution is reported. COMP exerts a distinct mechanism of interaction mainly defined by the pattern of hydrophobic core residues. PMID: 12426368
  10. COMP has a role in development of the extracellular matrix and in a cell culture model for pseudoachondroplasia PMID: 15579310
  11. COMP secretion is affected by the signal peptide PMID: 15749701
  12. Expression of COMP in both anulus fibrosus(AF) and nucleus pulposus(NP) of intervertebral disc(IVD). COMP is component of extracellular matrix of AF and NP, with lamellar distribution in AF. May play role in normal structure of IVD. PMID: 16778685
  13. ultrastructural distribution of COMP & TSP-4 & collagen fibril thickness in achilles tendon related to exercise; COMP immunolabeling decreased with longer running distance & was lower in pericellular & interterritorial compartments of high training rats PMID: 17882701
  14. To identify residues critical for the structure, stability, oligomerization and binding to vitamin D as well as two small molecules, all-trans-retinol and curcumin, an alanine-scanning mutagenesis study of cartilage oligomeric matrix protein is performed. PMID: 19681593

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Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Thrombospondin family
Tissue Specificity Expressed in differentiated and de-differentiated vascular smooth muscle cells (VSMCs) (at protein level).
Database Links

KEGG: rno:25304

STRING: 10116.ENSRNOP00000067037

UniGene: Rn.10343

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