Recombinant Human Angiotensin-converting enzyme (ACE), partial

Code CSB-YP001149HU
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Source Yeast
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Code CSB-EP001149HU
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Source E.coli
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Code CSB-EP001149HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001149HU
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Source Baculovirus
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Code CSB-MP001149HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
ACE 1; ACE; ACE T; ACE_HUMAN; ACE1; Angiotensin converting enzyme somatic isoform; Angiotensin converting enzyme testis specific isoform; Angiotensin I converting enzyme 1; Angiotensin I converting enzyme; Angiotensin I converting enzyme peptidyl dipeptidase A 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; Carboxycathepsin; CD 143; CD143; CD143 antigen; DCP 1; DCP; DCP1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; Kininase II; MGC26566; MVCD3; Peptidase P; Peptidyl dipeptidase A; soluble form; Testicular ECA
Homo sapiens (Human)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Gene References into Functions
  1. The study suggests that the ACE I/D polymorphism may contribute to mechanisms and intensity of DNA damage in hypertensive and normotensive individuals. PMID: 30480916
  2. study found a significant association between the ACE insertion/deletion polymorphism and Kawasaki disease risk - meta-analysis PMID: 29937869
  3. ACE gene I/D polymorphism was not associated with the risk of chronic obstructive pulmonary disease. PMID: 29716409
  4. aerobic exercise training differentially affects the ACE C- and N-domain activities, and the N-domain activity is dependent on ACE polymorphism. PMID: 29629833
  5. A significant difference was found between the patients with familial Mediterranean fever (FMF)-related amyloidosis and the control group as for genotype distribution of angiotensin converting enzyme (ACE) I/D variant. Based on these observations, the ACE I/D variant D/D genotypes implicate a possible risk in the FMF-related amyloidosis among Turkish population. PMID: 29891744
  6. Angiotensin-converting enzyme insertion/deletion gene polymorphism is associated with prostate cancer susceptibility. PMID: 29970692
  7. This study aimed to investigate the relationship between estimated training status (TS), blood pressure and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. PMID: 29923443
  8. This study shows that ACE gene polymorphism, particularly the D allele, is associated with worse functional outcome of ischaemic stroke patients. PMID: 29199539
  9. ACE gene polymorphisms were not associated with the development of preeclampsia in South African Black women. PMID: 29523271
  10. summary of current knowledge about circulating ACE elevation in patients with granulomatous and non-granulomatous diseases. PMID: 29928904
  11. This study found that patients with the DD genotype reduced the exogenous EPO requirement as compared to the II genotype. Further, D allele frequency was higher in patients with diabetic nephropathy as compared to I allele which implies that D allele is an independent risk factor for progression to CKD. PMID: 28457029
  12. Prevalence has been found of ACTN3 R577X and of ACE insertion / deletion gene polymorphisms in national and amateur Turkish athletes. PMID: 29729690
  13. The ACE and AGT gene polymorphisms are not associated with the progress of diabetes developing into retinopathy in Chinese patients with type 2 diabetes. PMID: 29378484
  14. Review/Meta-analysis: ACE I/D polymorphism may be a genetic molecular marker to predict systemic lupus erythematosus but not lupus nephritis. PMID: 29205894
  15. Association of insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) with depression in Chinese adolescents experiencing the 2008 Wenchuan earthquake. PMID: 28982269
  16. The ACE (I/D) gene polymorphism do not seem to have a significant effect on the development of clinical properties or cardiovascular comordities of acromegalic patients. PMID: 28712073
  17. polymorphisms in the eNOS "A/A" (homozygous mutant) and ACE "I/D" genotypes might contribute to the increased risk of NSCLC in the South Indian population. PMID: 27328622
  18. The study attempts to understand the distribution and extent of association of ACE I/D gene polymorphism with cardiometabolic risk factors among Bhils from rural and urban settings. PMID: 29435690
  19. Data suggest that the insertion/deletion (I/D) ACE (angiotensin converting enzyme) gene polymorphism may be associated with MI occurrence among younger patients. PMID: 29268798
  20. The analysis of genotype coexistence revealed a higher incidence of the combination of the ACE II and the PAI-1 4G/4G genotypes in the control group (10.0 vs.5.9% in control group; p = 0.17). CONCLUSIONS: The obtained results suggest no apparent association between the ACE I/D, PAI-1 4G/5G polymorphisms and increased RM susceptibility in the analyzed Polish population. PMID: 27321098
  21. An involvement of the ACE polymorphism in element imbalances in hypertension PMID: 28303511
  22. Concomitant presence of non-functional variant in ACTN3 gene decreased this beneficiary effect of ACE mutation on SBPR3. PMID: 29269700
  23. There were significant differences in sarcopenic obesity according to ACE I/D genotype, Women who were ACE DD presented lower risk of sarcopenic obesity than those in the ACE II and ACE ID groups PMID: 29130707
  24. Patients with Alzheimer's disease who were homozygous for angiotensin-converting enzyme (ACE) Insertion allele presented with a more rapid AD deterioration than did those who had other ACE genotypes, particularly those patients without hypertension. PMID: 27862810
  25. The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility. PMID: 27895197
  26. ACE DD genotype and overall frequency of D allele is significantly higher in patients with PPCM. Also, the presence of DD genotype is associated with worse systolic performance indices measured echocardiographically. PMID: 29455790
  27. There was an independent association of the angiotensin-converting enzyme polymorphism with central and ambulatory blood pressure in Chinese patients with Hypertension. PMID: 28834200
  28. expression not increased in the maternal vascular endothelium in subjects with preeclampsia compared with normal pregnant controls PMID: 28878298
  29. DD genotype and D allele of ACE gene I/D polymorphism might increase the risk of lymph node metastasis in colorectal cancer patients. PMID: 29032382
  30. The results suggest that ACE I/D polymorphism, high ACE activity, body mass index and oxidative damage may play key roles in the pathogenesis of preeclampsia in the Mexican population. PMID: 29153683
  31. SNPs in folate pathway genes MTHFR/ MTR/ACE and hyperhomocysteinemia have roles in risk of coronary artery disease. PMID: 28514598
  32. ACE I alleles are associated with dementia risk. PMID: 28657841
  33. Data indicate it is unlikely that ACE II genotype provides an advantage in endurance running. PMID: 29298672
  34. This study concludes that DD genotype is strongly associated with higher SBP in hypertensive patients. PMID: 29058472
  35. ACE binds to lysozyme and bilirubin, which regulate its conformation and shedding PMID: 27734897
  36. The presence of the ACE I-allele was associated with increased aerobic functional capacity after the aerobic interval training program. PMID: 29846435
  37. Study showed that dietary weight loss-induced changes in angiotensin-converting enzyme activity, free fatty acids and RBP4 independently contribute to weight regain prediction. PMID: 29122953
  38. Among the four haplotypes composed by ACE gene A2350G and I/D, haplotype G-D reached the statistical significance in two groups, and exhibited to be a risk factor for the development of EH, whose P < 0.001 and OR 95%CI = 1.639(1.435-1.872), while the other haplotypes were the protective factors and decreased the susceptibility to EH(P < 0.05). PMID: 29172745
  39. The serum ACE level could be a novel noninvasive, easy, accurate, and inexpensive marker of significant fibrosis stage in patients with chronic hepatitis B. PMID: 29085215
  40. ACE SNPs were not associated with bone density among lead workers. PMID: 29028685
  41. Study showed the association between rs4343 and susceptibility to migraine in a case-control population. PMID: 28626926
  42. Studied interleukin-1 receptor antagonist (IL-1Ra) and angiotensin-converting enzyme (ACE) I/D polymorphisms with regards to the susceptibility of patients to carpal tunnel syndrome. PMID: 28370589
  43. no correlation was found between the ACE and MTHFR polymorphisms in the development of T2DM. PMID: 29694640
  44. The ACE Ins/Del polymorphism was associated with body composition. Ins/Ins individuals had higher phase angle (PhA) and body cellular mass index (BCMI) values. Ins/Ins individuals displayed higher PhA and BCMI values only if norm-hydrated, while they showed values similar to Del carriers if dehydrated. PMID: 28315876
  45. The DD genotype for ACE was independently associated (b = -0.44, P = 0.007) with Alzheimer's disease patients in the island of IKARIA, Greece. PMID: 28379521
  46. The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of community-acquired pneumonia (CAP) in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients. PMID: 29028160
  47. ACE indel polymorphism is a risk factor for allergic rhinitis. (Meta-analysis) PMID: 28886328
  48. the ACE DD genotype may increase the risk of renal scar in children with vesicoureteral reflex [meta-analysis] PMID: 27506878
  49. The AA and GA genotypes of MTHFD1 G1958A, TT and GT genotypes of eNOS G894T and the AA and GA genotypes of ACE A2350G are risk factors for congenital heart defects. PMID: 28865601
  50. The ACE D allele in aMCI patients may increase the risk of cognitive impairment. A high serum ACE level possibly plays an important role in the incidence of aMCI. PMID: 28870562

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Involvement in disease
Ischemic stroke (ISCHSTR); Renal tubular dysgenesis (RTD); Microvascular complications of diabetes 3 (MVCD3); Intracerebral hemorrhage (ICH)
Subcellular Location
[Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein Families
Peptidase M2 family
Tissue Specificity
Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
Database Links

HGNC: 2707

OMIM: 106180

KEGG: hsa:1636

STRING: 9606.ENSP00000290866

UniGene: Hs.298469

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