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| Code | CSB-EP019307HU |
| Product Type | Recombinant Protein |
| Size | US$1726 |
| Uniprot No. | P62826 |
| Relevance | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Androgen receptor-associated protein 24 GTPase Ran Ras-like protein TC4 Ras-related nuclear protein |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | AAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL |
| Research Area | Cell Biology |
| Source | E.coli |
| Gene Names | RAN |
| Protein Names | Recommended name: GTP-binding nuclear protein Ran Alternative name(s): Androgen receptor-associated protein 24 GTPase Ran Ras-like protein TC4 Ras-related nuclear protein |
| Expression Region | 1-216aa |
| Tag Info | N-terminal GST-tagged |
| Mol. Weight | 51.3kDa |
| Protein Description | Full Length |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport. |
| Subcellular Location | Nucleus, Nucleus envelope, Cytoplasm, Melanosome |
| Protein Families | Small GTPase superfamily, Ran family |
| Tissue Specificity | Expressed in a variety of tissues. |
| Database Links |
HGNC: 9846 OMIM: 601179 KEGG: hsa:5901 STRING: 9606.ENSP00000376176 UniGene: Hs.10842 |
RAN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA019307GA01HU | RAN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003935 | RAN Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA122817 | RAN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA092188 | RAN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA558089 | RAN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA998992 | RAN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
RAN Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA019307ESR1HU | RAN Antibody | Human | ELISA, WB, IHC |
RAN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP019307HU CSB-BP019307HU CSB-MP019307HU |
Recombinant Human GTP-binding nuclear protein Ran(RAN) | Yeast Baculovirus Mammalian cell |
Recombinant Human Islet amyloid polypeptide protein(IAPP),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Ras-related protein Ral-B(RALB)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Sulfotransferase 1A1(Sult1a1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human LIM domain transcription factor LMO4(LMO4)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Nuclease-sensitive element-binding protein 1(Ybx1)
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Human Cellular tumor antigen p53(TP53)
Express system: Yeast
Species: Homo sapiens (Human)
