Recombinant Human Brachyury protein (T)

1. Brachyury expression in tumor samples is not a sensitive indicator of prognosis in chordomas PMID: 28094431
2. Notochordal transcription factor Brachyury gene duplication in sporadic chordoma PMID: 29026114
3. FGFR1/MAPK may be important for brachyury activation in lung cancer, and this pathway may be an appealing therapeutic target for a subset of brachyury-driven lung cancer. PMID: 27893433
4. our results indicate that Brachyury contributes to tumor chemotherapy resistance, constituting an attractive target for advanced prostate cancer patients PMID: 27049720
5. A strong association was observed between nuclear brachyury protein expression and the stage of disease, with nuclear brachyury being more predominant in metastatic vs primary tumors. PMID: 27580659
6. rs2305089 variant in T (brachyury) gene is associated with response to therapy in Spinal column chordoma. PMID: 27663388
7. Brachyury was significantly associated with estrogen receptor positive and human epidermal growth factor receptor 2 negative status; further study would be needed to clarify how it affects treatment prognosis. PMID: 28621227
8. Brachyury is a candidate marker for predicting the clinical efficacy of tamoxifen. PMID: 27621036
9. Overexpression of Brachyury in the cytoplasm is predictive of poor prognosis in gastrointestinal stromal tumors. PMID: 25995035
10. Results showed that the high expression of SMC1 often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury in triple-negative breast cancer cells. PMID: 26781859
11. The distinct expression patterns of T gene isoforms may contribute to the pathogenesis of skull base chordomas. PMID: 26435504
12. Brachyury expression promotes lung cancer cell proliferation and invasion, and correlates with reduced patient survival. PMID: 25683840
13. Nuclear brachyury expression is prevalent in embryonal carcinoma, seminoma, and small cell carcinoma of the lung but very rare in common carcinomas, sarcomas, and melanoma. PMID: 26099010
14. Elevated Brachyury facilitates hepatocellular carcinoma metastasis by promoting EMT via PTEN/Akt/Snail-dependent pathway. PMID: 25499255
15. we found that Brachyury expression was inversely correlated with CCL2 and CCL4 expression in human lung tumors PMID: 25744730
16. Brachyury plays an important role in regulating TGF beta 1-mediated renal epithelial mesenchymal transition and could be an attractive target for progression of renal disease therapies PMID: 25433496
17. The data illuminate the function of BRA in the context of human embryonic development and show that the regulatory role of BRA is context dependent. PMID: 26015544
18. the present study suggests that Brachyury plays an important role in prostate cancer aggressiveness and points, for the first time, to Brachyury as a significant predictor of poor prostate cancer prognosis PMID: 25009296
19. Brachyury separates chordoma from cytomorphologic mimics with high sensitivity and specificity in small biopsies. PMID: 24554551
20. Brachyury expression may useful for the differential diagnosis of renal hemangioblastoma from other neoplastic histological mimickers. [Review] PMID: 24591762
21. Brachyury knockdown reduces invasiveness and chemoresistance and radioresistance of cancer stem cells in vivo. PMID: 24504414
22. Importance of the T gene in the pathogenesis of both familial and sporadic chordoma. PMID: 24990759
23. Activated brachury is associated with chordoma. PMID: 24445144
24. The level of brachyury expression in breast cancer cells was positively associated with their ability to invade the extracellular matrix, efficiently form mammospheres in vitro, and resist the cytotoxic effect of docetaxel PMID: 24815864
25. Multiple abnormalities, consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal, are associated with mutations in the T (brachyury) gene. PMID: 24253444
26. High expression of Brachyury gene is associated with lung carcinoma. PMID: 23456319
27. We report two cases of recurrent EAC confirmed by the expression of brachyury arising from the distal femur and distal tibia and describe the imaging findings from radiography and MRI at initial diagnosis and at recurrence. PMID: 23653219
28. Common variants of PAX3 and T are associated with spina bifida. PMID: 23913553
29. results show that Brachyury expression is enhanced during TGF-beta1-induced epithelial-mesenchymal transition in human cancer cell lines and that a positive feedback loop is established between Brachyury and TGF-beta1 in mesenchymal-like tumor cells PMID: 23783250
30. Brachyury expression may attenuate cell cycle progression, enabling tumor cells to become less susceptible to chemotherapy and radiation in human carcinomas. PMID: 23788039
31. The results of this study suggested that brachyury-negative chordomas are biologically distinct from brachyury-positive chordomas and that T/brachyury might be an appropriate molecular therapeutic target for chordoma. PMID: 23965741
32. heterochromatin-specific nonhistone chromosomal protein HP-1 PMID: 23218904
33. Our findings present clinical evidence for an important role of Brachyury in EMT in oral SCC, and suggest that Brachyury and EMT patterns are useful prognostic markers. PMID: 23076115
34. Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes. PMID: 22833560
35. Functional significance of Brachyury in the developmental program of hematopoietic differentiation from embryonic stem cells. PMID: 22548442
36. An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. PMID: 22847733
37. Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics. PMID: 22446946
38. Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus. PMID: 22538805
39. Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity PMID: 22164283
40. BRACHYURY may regulate NANOG in mesenchymal-like CRC cells to impose a 'plastic-state', allowing competence of cells to respond to signals prompting invasion or metastasis. PMID: 21365650
41. Loss of p27(Kip)(1) causes an elongated/scatter cell-like phenotype involving up-regulation of Brachyury and Twist gene expression. PMID: 21478681
42. BRA was necessary for and preceded CDX2 expression. PMID: 21816365
43. DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas. PMID: 22007675
44. Brachyury expression predicts poor prognosis at early stages of colorectal cancer PMID: 21220197
45. The tumor cells were diffusely positive for brachyury and cytokeratin 19 on immunohistochemistry, suggesting that the tumor was extra-axial soft tissue chordoma. PMID: 21397407
46. This study confirms the specificity of brachyury for chordoma in the differential diagnostic distinction from the potential genitourinary mimics, germ cell tumors and metastatic clear cell renal cell carcinoma. PMID: 21102418
47. brachyury expressed in chordoma tumor cells, but not in benign notochoral cell rests that were coexistent. PMID: 20855213
48. findings show chromosomal aberrations resulting in gain of the T locus are common in sporadic chordomas and expression of this gene is critical for proliferation of chordoma cells in vitro PMID: 21171078
49. Exclusive brachyury expression in more than 90% of chordomas indicates its value as a unique, specific marker. PMID: 20670140
50. Human T and risk for neural tube defects. PMID: 11897834

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HGNC: 11515

OMIM: 182940

KEGG: hsa:6862

STRING: 9606.ENSP00000296946

UniGene: Hs.389457