ci Antibody

1. Ci influences the Hippo signaling via interaction with Hpo and Yki. PMID: 26403189
2. Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction. PMID: 25941387
3. Ci responds to and relays Hh signals in a precise manner to control target genes expressions and ensures proper Hh signal transduction. PMID: 25495033
4. findings reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling PMID: 26120032
5. The requirement for gene activation by Ci in the regions of low-to-moderate Hh signalling results in evolutionary pressure favouring weak binding sites in enhancers of certain Hh target genes. PMID: 24218631
6. CK2 regulated the stability of full-length Cubitus interruptus (Ci). PMID: 20876583
7. The last 3 zinc fingers of Ci-155 bind Cos2 in vitro. The zinc finger region, rather than the CDN domain, functions redundantly with the CORD domain to promote Hh-regulated Ci-155 proteolysis in wing discs. PMID: 20850429
8. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. PMID: 11955435
9. ci mediates hedgehog signaling to determine the anteroposterior compartment of Drosophila wing disc. PMID: 12791275
10. Cos2 recruits multiple kinases to efficiently phosphorylate Ci, and Hh inhibits Ci phosphorylation by specifically interfering with kinase recruitment. PMID: 15691767
11. Two unrelated transcription factors, Ci and NF-kappaB, use the same mechanism to undergo partial degradation by the proteasome in vivo. PMID: 16299518
12. Ci proteolysis is compromised, its specific activity is limited principally by Su(fu), and not by Cos2 cytoplasmic tethering or PKA phosphorylation. PMID: 17925225
13. Results present a model whereby the zinc finger region and lysine 750 together form a unique protection signal that prevents the complete degradation of Cubitus interruptus by the proteasome. PMID: 18625727
14. Cos2 motility regulates the amounts and activity of Ci that ultimately interpret the level of Hh to which cells are exposed. PMID: 18691888
15. identified PP4 and PP2A as phosphatases that influence Hh signaling by regulating Smo and Ci, respectively PMID: 19088085
16. The function of this transcription factor is regulated by a Ci complex that is part of the Hedgehog signaling pathway. PMID: 11476581

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KEGG: dme:Dmel_CG2125

STRING: 7227.FBpp0088245

UniGene: Dm.3166