5 Antibody

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Code	CSB-PA365450XA01EEB
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Target Background

Product Details

Full Product Name

Rabbit anti-Enterobacteria phage T7 (Bacteriophage T7) 5 Polyclonal antibody

Uniprot No.

P00581

Target Names

Alternative Names

5DNA-directed DNA polymerase antibody; EC 2.7.7.7 antibody; EC 3.1.11.- antibody; Gene product 5 antibody; Gp5 antibody

Raised in

Rabbit

Species Reactivity

Enterobacteria phage T7 (Bacteriophage T7)

Immunogen

Recombinant Enterobacteria phage T7 (Bacteriophage T7) 5 protein

Immunogen Species

Enterobacteria phage T7 (Bacteriophage T7)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Replicates viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction. Non-processive DNA polymerase that achieves processivity by binding to host thioredoxin (TrxA). This interaction increases the rate of dNTP incorporation to yield a processivity of approximately 800 nucleotides (nt) per binding event. Interacts with DNA helicase gp4 to coordinate nucleotide polymerization with unwinding of the DNA. The leading strand is synthesized continuously while synthesis of the lagging strand requires the synthesis of oligoribonucleotides by the primase domain of gp4.

Gene References into Functions

Data suggest replication loop is released at nick formed in lagging-strand DNA when polymerase (gp5) encounters previously synthesized Okazaki fragment (OF), releasing lagging-strand DNA, and retaining gp5 at replication fork for synthesis of next OF. PMID: 26620561
Results suggest that the interaction between the C-terminal tail of the helicase and the basic patch of gp5 is critical for initiation of strand-displacement synthesis. PMID: 21606333
Small angle X-ray scattering studies combined with nuclease footprinting reveal two conformations of T7 DNA polymerase, one in the free state and one upon binding to E. coli thioredoxin PMID: 20696935
single-molecule imaging approach to visualize the interaction of fluorescently labeled T7 DNA polymerase with double-stranded DNA PMID: 20080681
the thioredoxin-binding domain is a molecular switch that regulates the interaction of T7 DNA polymerase with other proteins of the replisome PMID: 15795374
Escherichia coli thioredoxin, the processivity factor, binds with bacteriophage T7 DNA polymerase and helicase PMID: 18757858
Results describe the nucleotidyl transfer reaction mechanism in the well-characterized high-fidelity replicative DNA polymerase from phage T7. PMID: 19389406

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Protein Families

DNA polymerase type-A family

Database Links

KEGG: vg:1261044

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5 Antibody

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