N Antibody

1. Proper assembly of multicellular mechanosensory organs requires a double-negative circuit involving miRNA-mediated suppression of a Notch repressor to assign non-neuronal cell fate. PMID: 29196461
2. Study shows that the trans- and cis- interactions between the ligand Ser and the Notch receptor regulate the cell number and size of the imaginal ring in drosophila. PMID: 29773559
3. Strat is required to localize Rab8 at the TGN, and rab8 phenocopies strat We propose that Strat and Rab8 act at the exit of the Golgi apparatus to regulate the sorting and the polarized distribution of Notch, Delta and Spdo. PMID: 29967125
4. Delta-Notch dependent boundary formation in the Drosophila large intestine PMID: 28950873
5. The authors found that Dl requires ubi for its full function, but can also signal in two ubi-independent modes, one dependent and one independent of Neur. Their analysis suggests that one important role of Dl protein ubiquitination by Mib1 is their release from cis-inhibitory interactions with Notch, enabling them to trans-activate Notch on adjacent cells. PMID: 28960177
6. AKAP200 is a novel tissue specific posttranslational regulator of Notch, maintaining high Notch protein levels and thus promoting Notch signaling. PMID: 29309414
7. In the nervous system the subperineurial glia (SPG) are unique in using both the endocycle and endomitosis to grow. In the brain, the majority of SPG initially endocycle, then switch to endomitosis during larval development. The Notch signaling pathway and the String Cdc25 phosphatase are crucial for the endocycle versus endomitosis choice. PMID: 29440220
8. During ovarian germline stem cell niche formation, the status of Notch signaling in the cell can be reprogrammed. This is controlled via steroid-induced miR-125, which targets a negative regulator of Notch signaling, Tom. PMID: 29361571
9. Notch-Abl axonal signaling requires proteolytic cleavage events that initiate canonical Notch signaling. Some Notch protein is tyrosine phosphorylated, this form of the protein is selectively associated with Disabled and Trio, and relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate. PMID: 29343637
10. Data show that the wave speed control and salt and pepper pattern formation required distinct threshold levels of Notch signaling activity. PMID: 27535937
11. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. PMID: 29051265
12. Grh, AbdA, and Exd function together at multiple motifs on the apoptotic enhancer. Exd-Grh-Notch work with different Hox genes through region specific enhancers to pattern respective segments of larval central nervous system. PMID: 29023471
13. Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain PMID: 28325554
14. and ecdysone signaling pathways synergistically regulate Cut expression for proper DV boundary formation in the wing disc PMID: 27117286
15. biochemical analysis shows that A2BP1 is part of the Suppressor of Hairless [Su(H)] complex in the presence and absence of Notch PMID: 28174239
16. Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation. PMID: 28242614
17. reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning. PMID: 27226324
18. This work not only elucidates a key mechanism of Notch-mediated maintenance of type II NB self-renewal and identity, but also reveals a novel function of Erm. PMID: 27151950
19. To identify structural principles underlying polyQ tracts in disordered regulatory domains, study analyzed deep evolution of metazoan Notch polyQ tracts. Results suggest that intrinsically disordered interference arrays featuring carboxamide and polyQ enrichment may constitute coupled proteodynamic modulators of solenoids. PMID: 28319202
20. During antennal development, expression of the selector genes Lim1 and Dll was sharply segregated. Notch signaling induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold. PMID: 28708823
21. our data indicate that the MLF/DnaJ-1-dependent increase in Lz level allows the repression of Notch expression and signaling to prevent aberrant blood cell development. Thus our findings establish a functional link between MLF and the co-chaperone DnaJ-1 to control RUNX transcription factor activity and Notch signaling during blood cell development in vivo. PMID: 28742844
22. The conserved MAPK site in E(spl)-M8, an effector of Drosophila notch signaling, controls repressor activity during eye development. PMID: 27428327
23. Notch signaling directly regulates ban expression at the transcriptional level to impact cell growth. PMID: 28520736
24. Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development. PMID: 28140449
25. These data provide foundational information for future studies investigating the mechanisms of how O-glycosylation regulates Notch activity. PMID: 27268051
26. N activity is required to promote dpn transcription; only in R7 photoreceptor precursors does the removal of Ttk coincide with high N activity; and only in this cell does Dpn expression result PMID: 27427987
27. lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate. PMID: 26727288
28. the monosaccharide O-glucose and terminal dixylose of O-glucose-linked saccharides have distinct activities in Notch trafficking, although a loss of these activities is compensated for by the presence of monosaccharide O-fucose. PMID: 27129198
29. Rabex-5 plays an important role in Drosophila hematopoiesis and might serve as an axis coordinating Ras and Notch signaling in the lymph gland. PMID: 26567216
30. Reducing levels of old intermediate neural progenitor (INP) temporal transcription factor Eyeless/Pax6 allows Notch signaling to promote dedifferentiation of INP progeny into ectopic INPs, creating a proliferative mass of ectopic progenitors in the brain. PMID: 26585279
31. Drosophila adult muscle precursors display homing behavior to muscle niche and the niche-driven Insulin-Notch-dMyc cascade plays a key role in setting the activated state of adult muscle precursors. PMID: 26650355
32. Data suggest that gliolectin is a positive regulator of Notch receptor signalling during wing development. PMID: 26505251
33. a Notch/Su(H)/E(spl)-HLH cascade specifically controls daughter, but not progenitor proliferation PMID: 27070787
34. Data show that Notch protein functions solely by the canonical pathway in regulating physiological plasticity. PMID: 26986723
35. endocycle entry in anterior follicle cells than those in the posterior, identified that the insulin-PI3K pathway participates in the precise M/E switch, and suggested Nejire as a cofactor of Notch signaling during oogenesis PMID: 26205122
36. Notch protein regulates Dys expression during Drosophila leg development. PMID: 25329825
37. NICD signaling is not sufficient to explain Nfull-induced Long-term memory enhancement. PMID: 25791355
38. We further show that Notch in ORNs acts by both canonical cleavage-dependent and non-canonical cleavage-independent pathways. The Notch ligand Delta (Dl) in PNs switches the balance between the pathways. PMID: 26011623
39. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch-Src synergy. PMID: 26222204
40. The role of the Hippo pathway effectors Yorkie and Scalloped in mediating and facilitating Notch signaling-mediated lineage specification in the lymph gland was studied. PMID: 26151599
41. we show that the binding of the fly RAM domain of the NICD to CSL does not affect interactions of the corepressor Hairless with CSL PMID: 25650119
42. Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium. PMID: 25951303
43. By altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription. PMID: 25157415
44. A novel role of Notch signaling in controlling germline stem cell-niche adhesion in response to aging. PMID: 25521289
45. Notch activation leads to robust increase in H3K56 acetylation. PMID: 26069324
46. A branched pathway downstream of Notch in which Bowl functions to direct hub cell assembly in parallel to Tj downregulation, is reported. PMID: 26092848
47. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor PMID: 25217625
48. Data indicate that Notch signaling pathway components are expressed in adult malpighian tubules. PMID: 25527105
49. study reveals that Chip is a novel interacting partner of Notch PMID: 25597954
50. Notch signaling activates the expression of extramacrochaetae (emc), which encodes a helix-loop-helix (HLH) transcription factor. Emc, in turn, then forms a biochemical complex with Da. PMID: 25977368

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KEGG: dme:Dmel_CG3936

STRING: 7227.FBpp0070483