Code | CSB-RA012767A191phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
IP | 1:200-1:1000 |
Phospho-LAT (Y191) antibody CSB-RA012767A191phHU is a recombinant monoclonal antibody expressed by the plasmids containing the coding sequence of the LAT monoclonal antibody in the host cell lines. The synthesized peptide derived from phospho-LAT at Y191 residue was used to immunize the animals to get and isolate the LAT monoclonal antibody. This recombinant antibody against the phosphorylated LAT at Y191 is a rabbit IgG and can react with human samples. It underwent affinity-chromatography purification. And it can be used in ELISA, WB, IHC, IF, and IP applications.
LAT is a palmitoylated and membrane-associated adaptor protein phosphorylated at multiple tyrosine residues (e.g. Tyr132, Tyr171, Tyr191, and Tyr226) by ZAP-70 upon TCR stimulation. Phospho-LAT is activated and serves as an essential scaffold for the assembly of TCR-coupled signaling complexes that mediate productive T cell activation.
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