Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot No.

Q9IK90

Alternative Names

M; Matrix protein; Protein M

Species

Nipah virus

Expression Region

1-352

Target Protein Sequence

MEPDIKSISS ESMEGVSDFS PSSWEHGGYL DKVEPEIDEN GSMIPKYKIY TPGANERKYN NYMYLICYGF VEDVERTPET GKRKKIRTIA AYPLGVGKSA SHPQDLLEEL CSLKVTVRRT AGSTEKIVFG SSGPLNHLVP WKKVLTSGSI FNAVKVCRNV DQIQLDKHQA LRIFFLSITK LNDSGIYMIP RTMLEFRRNN AIAFNLLVYL KIDADLSKMG IQGSLDKDGF KVASFMLHLG NFVRRAGKYY SVDYCRRKID RMKLQFSLGS IGGLSLHIKI NGVISKRLFA QMGFQKNLCF SLMDINPWLN RLTWNNSCEI SRVAAVLQPS IPREFMIYDD VFIDNTGRIL KG

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane. Transits through the host nucleus before gaining the functional ability to localize and bud from the plasma membrane. Mediates together with fusion protein the incorporation of the glycoprotein to the viral particles. Participates also in the inhibition of the host interferon type I antiviral response by interacting with and thereby inhibiting host TRIM6.

Gene References into Functions

Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains. PMID: 27622505
These data demonstrate that the M protein is not absolutely required for the production of cell-free virus but is necessary for proper assembly and release of stable infectious virus particles. PMID: 26676785
Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. PMID: 17005661
The results indicate that NiV M, F, and G each possess some ability to bud from expressing cells, and that co-expression of these viral proteins results in a more organized budding process with M playing a central role. PMID: 17204159
The YPLGVG motif in the M protein plays an important role in Nipah virus budding. PMID: 19000317

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Subcellular Location

Virion. Host cytoplasm. Host cell membrane. Host nucleus.

Protein Families

Morbillivirus/respirovirus/rubulavirus M protein family

Database Links

KEGG: vg:920953

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Recombinant Nipah virus Matrix protein (M)

Product Details

Customer Reviews and Q&A

Target Background

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