Recombinant Mouse Protein hairless (Hr), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

Uniprot No.

Q61645

Alternative Names

HrLysine-specific demethylase hairless; EC 1.14.11.-

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.

Gene References into Functions

Changes in the expression of Hr result in hair loss or regrowth. PMID: 28679963
hypomorphic mutation essential for the full development of diet-induced pruritic atopic skin PMID: 26998821
This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/beta-catenin signaling in the absence of the hairless protein. PMID: 28765044
the putrescine-HR negative regulatory loop may have a large impact on epidermal homeostasis and hair follicle cycling PMID: 24079733
HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin. PMID: 23702391
Mutation within mouse hr protein leads to phenotype of hairlessness. PMID: 23903062
Hairless is required for adipocyte differentiation. PMID: 22964757
Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice PMID: 22761871
Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID: 21777520
Hr evokes an anti-apoptotic response by disrupting a p53 dependent pathway involving Bcl2 family members. PMID: 20886113
Hr mutants display partial hair loss at an early age and progress to near alopecia. PMID: 19897589
Mutation of the Hr gene results in congenital hair loss in both mice and men PMID: 20087431
novel nonsense mutation (Hrrh-R) and molecular basis for hair loss and role of Hr in hair follicle biology PMID: 20080498
hairless phenotype in CR rats is not allelic with mouse hairless PMID: 11926302
This thyroid hormone-regulated corepressor associates with histone deacetylases in neonatal rat brain. PMID: 12403844
HR regulates the timing of epithelial cell differentiation in both the epidermis and hair follicle PMID: 15280217
Two polymorphisms and a homozygous transition for a G-->A at nucleotide position 3110 (exon 12) leading to the substitution of tryptophan by a nonsense codon, designated W911X. This allele was named rhinocerotic and short-lived, with the symbol hr(rhsl). PMID: 15955095
HR regulates the precise timing of Wnt signaling required for hair follicle regeneration. PMID: 16195376
Results provided new data for SNPs in Hr gene. PMID: 16378938
A novel missense mutation in the hr gene causes irreversible alopecia. PMID: 16455232
TRalpha is the major thyroid hormone receptor regulating hairless expression in the cerebellum of young mouse pups PMID: 16571082
Hr(N) does not appear to be an allele of Hr but may result from a mutation in a closely linked gene or from a regulatory mutation in Hr. PMID: 17330134
HR bmh protein displays an abnormal cellular localization in transfected cell lines, as well as in the epidermis and hair follicle of bmh mutant mice PMID: 17657241
A T-to-A transversion mutation in Hr causes abnormal hair follicle morphogenesis in mouse. PMID: 19513791

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Involvement in disease

Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

Subcellular Location

Nucleus.

Tissue Specificity

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Database Links

KEGG: mmu:15460

STRING: 10090.ENSMUSP00000022691

UniGene: Mm.7598

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Recombinant Mouse Protein hairless (Hr), partial

Product Details

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