Recombinant Rabies virus Glycoprotein (G), partial

A target DNA fragment corresponding to 20-459aa of Rabies virus (strain India) (RABV) was expressed with N-terminal 6xHis-tags in yeast. The resulting protein is the Yeast-expressed Recombinant Rabies Virus Glycoprotein (G). Its purity is greater than 90% as determined by SDS-PAGE. And it contains 440 amino acids and has a calculated molecular weight of 51.4 kDa. As the only surface protein of the rabies virion, the RABV G protein can induce the production of virus-neutralizing antibodies (VNA).

Rabies virus G is a component constituting the envelope of the rabies virus, which is the causative agent of rabies. Rabies is an ancient zoonotic disease that causes tens of thousands of deaths around the globe annually. RABV G is a key determinant for the induction of innate immune responses and consequent pathogenesis. The binding of RABV G to neural receptors such as acetylcholine receptor or neural cell adhesion molecules (NCAM), leading to exclusive neurotropism and neuroinvasiveness of RABV.